Expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women presenting pelvic organ prolapse

• Published in: Folia histochemica et cytobiologica 2011-01, Vol.49 (3), p.521-527
• Main Authors: Zbucka-Kretowska, Monika, Marcus-Braun, Naama, Eboue, Cyril, Abeguile, Geneviève, Wolczynski, Slawomir, Kottler, Marie Laure, Von Theobald, Peter
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biopsy; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Estrogen Receptor beta - genetics; Estrogen Receptor beta - metabolism; Estrogen receptors; Estrogens; Female; Humans; Menopause; Middle Aged; Modulators; mRNA; Pathogenesis; Pelvic Floor - pathology; Pelvic Floor - physiology; Pelvic Floor - surgery; Pelvic organ prolapse; Pelvic Organ Prolapse - drug therapy; Pelvic Organ Prolapse - metabolism; Pelvic Organ Prolapse - surgery; Pelvis; Post-menopause; Postmenopause - metabolism; Premenopause; Premenopause - metabolism; Receptors; Selective estrogen receptor modulators; Selective Estrogen Receptor Modulators - metabolism; Selective Estrogen Receptor Modulators - therapeutic use
• ISSN: 0239-8508; 1897-5631
• DOI: 10.5603/FHC.2011.0073

The precise role of estrogen in the pathogenesis of pelvic organ prolapse (POP) is still unclear, while the results concerning the effect of selective estrogen receptor modulators on pelvic organ prolapse are contradictory. Our aim was to test whether alteration in the expression of estrogen receptors in the pelvic floor of pre- and post-menopausal women is related to genital prolapse status. The mRNA levels of ERα and ERβ in 60 biopsy specimens were measured. Significantly higher expression of ERα and higher ERα/ERβ ratio were demonstrated in post-menopausal women compared to pre-menopausal women. Higher expression of ERα and higher ERα/ERβ ratio were detected in all studied groups with POP, thus it did not reach significance in the post-menopausal group. Pre-menopausal and post-menopausal women presenting pelvic organ prolapse had no difference in the ERα expression. Our preliminary study may indicate that pelvic organ prolapse is associated with higher expression of ERα/ERβ in the pelvic floor of both pre- and post-menopausal women; thus not reaching statistical significance in the post-menopausal women was probably due to the group's size. We believe that the inevitable changes in the estrogen receptor expression over women's different lifetimes may affect the risk of genital prolapse progression, and might contribute to the further search for appropriate selective estrogen receptor modulators as a treatment for women with pelvic organ prolapse.