Head and neck osteosarcoma

Abstract Objective The objective of the study was to discuss the optimal management and treatment outcomes for patients with head and neck osteosarcomas. Study Design Review article. Methods Review of the pertinent literature. Results Osteosarcomas account for approximately 1% or less of all head an...

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Bibliographic Details
Published in:American journal of otolaryngology 2011-11, Vol.32 (6), p.597-600
Main Authors: Mendenhall, William M., MD, Fernandes, Rui, DMD, MD, Werning, John W., MD, Vaysberg, Mikhail, DO, Malyapa, Robert S., MD, PhD, Mendenhall, Nancy P., MD
Format: Article
Language:English
Subjects:
Age Distribution
Biological and medical sciences
Cancer therapies
Chemotherapy
Disease-Free Survival
Diseases of the osteoarticular system
Female
Head and Neck Neoplasms - mortality
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - radiotherapy
Head and Neck Neoplasms - surgery
Humans
Incidence
Male
Medical sciences
Multivariate analysis
Neck Dissection - methods
Neoplasm Invasiveness - pathology
Neoplasm Staging
Osteosarcoma - epidemiology
Osteosarcoma - pathology
Osteosarcoma - surgery
Otolaryngology
Otorhinolaryngology. Stomatology
Prognosis
Radiotherapy, Adjuvant
Risk Assessment
Sex Distribution
Surgery
Surgical outcomes
Survival Analysis
Tomography
Treatment Outcome
Tumors
Tumors of striated muscle and skeleton
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Summary:Abstract Objective The objective of the study was to discuss the optimal management and treatment outcomes for patients with head and neck osteosarcomas. Study Design Review article. Methods Review of the pertinent literature. Results Osteosarcomas account for approximately 1% or less of all head and neck cancers. The vast majority occur in the mandible and maxilla. The median age is in the fourth decade, with a wide range. They are more likely to recur locally after treatment and distant metastases are observed less often than with the more common osteosarcomas arising in the long bones. The optimal treatment is complete resection. The role of adjuvant chemotherapy is ill-defined. The vast majority of recurrences are observed within 5 years. The 5-year disease-specific and overall survival rates are approximately 60% to 70%. Conclusions Osteosarcoma of the head and neck is a rare entity that occurs primarily in the mandible and maxilla. The optimal treatment is surgery. Adjuvant radiotherapy should be considered for those with close or positive margins. The role of adjuvant chemotherapy is ill-defined. The likelihood of cure is approximately 60% to 70%.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2010.09.002