Loading…
Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer
Background and Objectives Leakage has been shown to adversely affect survival in patients undergoing surgery for gastrointestinal malignancies. However, the effect of leakage following radical gastrectomy in patients with gastric cancer remains unclear. Methods In total, 478 patients with advanced g...
Saved in:
| Published in: | Journal of surgical oncology 2011-12, Vol.104 (7), p.734-740 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4565-301ad93f06bccd04f8f385e6b39380acda4e9950a6e6757d82fd394da717e7023 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4565-301ad93f06bccd04f8f385e6b39380acda4e9950a6e6757d82fd394da717e7023 |
| container_end_page | 740 |
| container_issue | 7 |
| container_start_page | 734 |
| container_title | Journal of surgical oncology |
| container_volume | 104 |
| creator | Yoo, Han Mo Lee, Han Hong Shim, Jung Ho Jeon, Hae Myung Park, Cho Hyun Song, Kyo Young |
| description | Background and Objectives
Leakage has been shown to adversely affect survival in patients undergoing surgery for gastrointestinal malignancies. However, the effect of leakage following radical gastrectomy in patients with gastric cancer remains unclear.
Methods
In total, 478 patients with advanced gastric cancer who underwent surgery with curative intent were reviewed. Anastomosis or duodenal stump leakage was diagnosed clinically or radiologically. Risk factors for leakage were evaluated by univariate and multivariate analyses. The impact of leakage on patient survival was analyzed using the Kaplan–Meier method.
Results
Leakage was diagnosed in 32 of 478 patients (6.7%); 14 patients (2.9%) exhibited esophagojejunal anastomotic leakage, 14 (2.9%) showed duodenal stump leakage, and four (0.8%) showed gastroduodenal anastomotic leakage. Poor performance status [odds ratio (OR): 4.01, 95% confidence interval (CI): 1.80–8.93] and tumor location (OR: 3.74, 95% CI: 1.56–8.89) were risk factors for postoperative leakage. Overall mean survival of patients with leakage was significantly lower than that of patients without leakage (30.5 vs. 96.2 months; P |
| doi_str_mv | 10.1002/jso.22045 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_901642352</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>901642352</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4565-301ad93f06bccd04f8f385e6b39380acda4e9950a6e6757d82fd394da717e7023</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhi0EokvhwB9AljhUPaQdfyY-ooouRVUrvoTExfLak8jbbLLYyZb-e7JN2wMSp9HMPO-r0byEvGVwwgD46Tr3J5yDVM_IgoHRhQFTPSeLaccLWRo4IK9yXgOAMVq-JAeclYYbqRakvcLGDXGHNG62zg-0r2mL7sY1SPuO5jHt4s61-_F24rAbMh27gKnpY9dQP6ZZnTCjH-IkqftEXdi5zmOgjctDip76fZtekxe1azO-eaiH5Mf5x-9nn4rL6-XF2YfLwkulVSGAuWBEDXrlfQBZV7WoFOqVMKIC54OTaIwCp1GXqgwVr4MwMriSlVgCF4fkaPbdpv73iHmwm5g9tq3rsB-zNcC05ELtyff_kOt-TN10nGVKcQVSGzNRxzPlU59zwtpuU9y4dGcZ2H0CdkrA3icwse8eHMfVBsMT-fjyCTidgdvY4t3_neznb9ePlsWsiHnAP08Kl26sLkWp7M-rpVVfFV_-Yl-sEn8BiYGffw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1552504699</pqid></control><display><type>article</type><title>Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Yoo, Han Mo ; Lee, Han Hong ; Shim, Jung Ho ; Jeon, Hae Myung ; Park, Cho Hyun ; Song, Kyo Young</creator><creatorcontrib>Yoo, Han Mo ; Lee, Han Hong ; Shim, Jung Ho ; Jeon, Hae Myung ; Park, Cho Hyun ; Song, Kyo Young</creatorcontrib><description>Background and Objectives
Leakage has been shown to adversely affect survival in patients undergoing surgery for gastrointestinal malignancies. However, the effect of leakage following radical gastrectomy in patients with gastric cancer remains unclear.
Methods
In total, 478 patients with advanced gastric cancer who underwent surgery with curative intent were reviewed. Anastomosis or duodenal stump leakage was diagnosed clinically or radiologically. Risk factors for leakage were evaluated by univariate and multivariate analyses. The impact of leakage on patient survival was analyzed using the Kaplan–Meier method.
Results
Leakage was diagnosed in 32 of 478 patients (6.7%); 14 patients (2.9%) exhibited esophagojejunal anastomotic leakage, 14 (2.9%) showed duodenal stump leakage, and four (0.8%) showed gastroduodenal anastomotic leakage. Poor performance status [odds ratio (OR): 4.01, 95% confidence interval (CI): 1.80–8.93] and tumor location (OR: 3.74, 95% CI: 1.56–8.89) were risk factors for postoperative leakage. Overall mean survival of patients with leakage was significantly lower than that of patients without leakage (30.5 vs. 96.2 months; P < 0.001). Leakage was one of the independent predictive factor for overall survival [hazard ratio (HR): 3.58, 95% CI: 2.29–5.59].
Conclusions
Postoperative inflammation due to leakage is a negative prognostic factor for patients with advanced gastric cancer. J. Surg. Oncol. 2011; 104:734–740. © 2011 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.22045</identifier><identifier>PMID: 21792945</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>advanced gastric cancer ; Anastomosis, Surgical - adverse effects ; Anastomosis, Surgical - methods ; Anastomotic Leak - epidemiology ; Anastomotic Leak - mortality ; curative surgery ; Female ; Gastrectomy ; Humans ; inflammation ; Korea - epidemiology ; leakage ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Prevalence ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Stomach Neoplasms - mortality ; Stomach Neoplasms - surgery ; survival ; Survival Rate</subject><ispartof>Journal of surgical oncology, 2011-12, Vol.104 (7), p.734-740</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4565-301ad93f06bccd04f8f385e6b39380acda4e9950a6e6757d82fd394da717e7023</citedby><cites>FETCH-LOGICAL-c4565-301ad93f06bccd04f8f385e6b39380acda4e9950a6e6757d82fd394da717e7023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21792945$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoo, Han Mo</creatorcontrib><creatorcontrib>Lee, Han Hong</creatorcontrib><creatorcontrib>Shim, Jung Ho</creatorcontrib><creatorcontrib>Jeon, Hae Myung</creatorcontrib><creatorcontrib>Park, Cho Hyun</creatorcontrib><creatorcontrib>Song, Kyo Young</creatorcontrib><title>Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Background and Objectives
Leakage has been shown to adversely affect survival in patients undergoing surgery for gastrointestinal malignancies. However, the effect of leakage following radical gastrectomy in patients with gastric cancer remains unclear.
Methods
In total, 478 patients with advanced gastric cancer who underwent surgery with curative intent were reviewed. Anastomosis or duodenal stump leakage was diagnosed clinically or radiologically. Risk factors for leakage were evaluated by univariate and multivariate analyses. The impact of leakage on patient survival was analyzed using the Kaplan–Meier method.
Results
Leakage was diagnosed in 32 of 478 patients (6.7%); 14 patients (2.9%) exhibited esophagojejunal anastomotic leakage, 14 (2.9%) showed duodenal stump leakage, and four (0.8%) showed gastroduodenal anastomotic leakage. Poor performance status [odds ratio (OR): 4.01, 95% confidence interval (CI): 1.80–8.93] and tumor location (OR: 3.74, 95% CI: 1.56–8.89) were risk factors for postoperative leakage. Overall mean survival of patients with leakage was significantly lower than that of patients without leakage (30.5 vs. 96.2 months; P < 0.001). Leakage was one of the independent predictive factor for overall survival [hazard ratio (HR): 3.58, 95% CI: 2.29–5.59].
Conclusions
Postoperative inflammation due to leakage is a negative prognostic factor for patients with advanced gastric cancer. J. Surg. Oncol. 2011; 104:734–740. © 2011 Wiley Periodicals, Inc.</description><subject>advanced gastric cancer</subject><subject>Anastomosis, Surgical - adverse effects</subject><subject>Anastomosis, Surgical - methods</subject><subject>Anastomotic Leak - epidemiology</subject><subject>Anastomotic Leak - mortality</subject><subject>curative surgery</subject><subject>Female</subject><subject>Gastrectomy</subject><subject>Humans</subject><subject>inflammation</subject><subject>Korea - epidemiology</subject><subject>leakage</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prevalence</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - surgery</subject><subject>survival</subject><subject>Survival Rate</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0EokvhwB9AljhUPaQdfyY-ooouRVUrvoTExfLak8jbbLLYyZb-e7JN2wMSp9HMPO-r0byEvGVwwgD46Tr3J5yDVM_IgoHRhQFTPSeLaccLWRo4IK9yXgOAMVq-JAeclYYbqRakvcLGDXGHNG62zg-0r2mL7sY1SPuO5jHt4s61-_F24rAbMh27gKnpY9dQP6ZZnTCjH-IkqftEXdi5zmOgjctDip76fZtekxe1azO-eaiH5Mf5x-9nn4rL6-XF2YfLwkulVSGAuWBEDXrlfQBZV7WoFOqVMKIC54OTaIwCp1GXqgwVr4MwMriSlVgCF4fkaPbdpv73iHmwm5g9tq3rsB-zNcC05ELtyff_kOt-TN10nGVKcQVSGzNRxzPlU59zwtpuU9y4dGcZ2H0CdkrA3icwse8eHMfVBsMT-fjyCTidgdvY4t3_neznb9ePlsWsiHnAP08Kl26sLkWp7M-rpVVfFV_-Yl-sEn8BiYGffw</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Yoo, Han Mo</creator><creator>Lee, Han Hong</creator><creator>Shim, Jung Ho</creator><creator>Jeon, Hae Myung</creator><creator>Park, Cho Hyun</creator><creator>Song, Kyo Young</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer</title><author>Yoo, Han Mo ; Lee, Han Hong ; Shim, Jung Ho ; Jeon, Hae Myung ; Park, Cho Hyun ; Song, Kyo Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4565-301ad93f06bccd04f8f385e6b39380acda4e9950a6e6757d82fd394da717e7023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>advanced gastric cancer</topic><topic>Anastomosis, Surgical - adverse effects</topic><topic>Anastomosis, Surgical - methods</topic><topic>Anastomotic Leak - epidemiology</topic><topic>Anastomotic Leak - mortality</topic><topic>curative surgery</topic><topic>Female</topic><topic>Gastrectomy</topic><topic>Humans</topic><topic>inflammation</topic><topic>Korea - epidemiology</topic><topic>leakage</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prevalence</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - surgery</topic><topic>survival</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoo, Han Mo</creatorcontrib><creatorcontrib>Lee, Han Hong</creatorcontrib><creatorcontrib>Shim, Jung Ho</creatorcontrib><creatorcontrib>Jeon, Hae Myung</creatorcontrib><creatorcontrib>Park, Cho Hyun</creatorcontrib><creatorcontrib>Song, Kyo Young</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoo, Han Mo</au><au>Lee, Han Hong</au><au>Shim, Jung Ho</au><au>Jeon, Hae Myung</au><au>Park, Cho Hyun</au><au>Song, Kyo Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>104</volume><issue>7</issue><spage>734</spage><epage>740</epage><pages>734-740</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Background and Objectives
Leakage has been shown to adversely affect survival in patients undergoing surgery for gastrointestinal malignancies. However, the effect of leakage following radical gastrectomy in patients with gastric cancer remains unclear.
Methods
In total, 478 patients with advanced gastric cancer who underwent surgery with curative intent were reviewed. Anastomosis or duodenal stump leakage was diagnosed clinically or radiologically. Risk factors for leakage were evaluated by univariate and multivariate analyses. The impact of leakage on patient survival was analyzed using the Kaplan–Meier method.
Results
Leakage was diagnosed in 32 of 478 patients (6.7%); 14 patients (2.9%) exhibited esophagojejunal anastomotic leakage, 14 (2.9%) showed duodenal stump leakage, and four (0.8%) showed gastroduodenal anastomotic leakage. Poor performance status [odds ratio (OR): 4.01, 95% confidence interval (CI): 1.80–8.93] and tumor location (OR: 3.74, 95% CI: 1.56–8.89) were risk factors for postoperative leakage. Overall mean survival of patients with leakage was significantly lower than that of patients without leakage (30.5 vs. 96.2 months; P < 0.001). Leakage was one of the independent predictive factor for overall survival [hazard ratio (HR): 3.58, 95% CI: 2.29–5.59].
Conclusions
Postoperative inflammation due to leakage is a negative prognostic factor for patients with advanced gastric cancer. J. Surg. Oncol. 2011; 104:734–740. © 2011 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21792945</pmid><doi>10.1002/jso.22045</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-4790 |
| ispartof | Journal of surgical oncology, 2011-12, Vol.104 (7), p.734-740 |
| issn | 0022-4790 1096-9098 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_901642352 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | advanced gastric cancer Anastomosis, Surgical - adverse effects Anastomosis, Surgical - methods Anastomotic Leak - epidemiology Anastomotic Leak - mortality curative surgery Female Gastrectomy Humans inflammation Korea - epidemiology leakage Logistic Models Male Middle Aged Multivariate Analysis Prevalence Proportional Hazards Models Prospective Studies Risk Factors Stomach Neoplasms - mortality Stomach Neoplasms - surgery survival Survival Rate |
| title | Negative impact of leakage on survival of patients undergoing curative resection for advanced gastric cancer |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T11%3A14%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Negative%20impact%20of%20leakage%20on%20survival%20of%20patients%20undergoing%20curative%20resection%20for%20advanced%20gastric%20cancer&rft.jtitle=Journal%20of%20surgical%20oncology&rft.au=Yoo,%20Han%20Mo&rft.date=2011-12-01&rft.volume=104&rft.issue=7&rft.spage=734&rft.epage=740&rft.pages=734-740&rft.issn=0022-4790&rft.eissn=1096-9098&rft_id=info:doi/10.1002/jso.22045&rft_dat=%3Cproquest_cross%3E901642352%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4565-301ad93f06bccd04f8f385e6b39380acda4e9950a6e6757d82fd394da717e7023%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1552504699&rft_id=info:pmid/21792945&rfr_iscdi=true |