Differential expression of ABC transporters (MDR1, MRP1, BCRP) in developing human embryos

Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistance (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal...

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Bibliographic Details
Published in:Journal of molecular histology 2011-12, Vol.42 (6), p.567-574
Main Authors: Konieczna, A., Erdösová, B., Lichnovská, R., Jandl, M., Čížková, K., Ehrmann, J.
Format: Article
Language:English
Subjects:
ATP Binding Cassette Transporter, Sub-Family B - biosynthesis
ATP Binding Cassette Transporter, Sub-Family B - genetics
ATP Binding Cassette Transporter, Sub-Family B - metabolism
ATP-Binding Cassette Transporters - biosynthesis
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
Biomedical and Life Sciences
Biomedicine
Cell Biology
Developmental Biology
Drug Resistance, Multiple
Embryonic Development - genetics
Embryonic Development - physiology
Gene Expression
Humans
Intestines - embryology
Kidney - embryology
Life Sciences
Liver - embryology
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Summary:Three ABC transporters (MDR1, MRP1, BCRP), belonging to the family of multidrug resistance (MDR) proteins, play a crucial role in the protection mechanisms during embryogenesis and mediate drug resistance in cancer cells. The distribution of these transporters in the series of human embryonal/fetal intestine, liver and kidneys of various stages of intrauterine development (IUD) by indirect two-step immunohistochemical method was investigated. The organ- and age-specific expression patterns of these transporters were depicted and compared with the expression in adult organs. The evaluation of intestine and liver samples demonstrate differences in expression pattern of ABC transporters during IUD. On the contrary, in kidneys the age-specific localization was not observed. However, the increasing positivity from the kidney surface towards deeper, more differentiated parts was found. Hopefully, our study may contribute to elucidation of the role of multidrug resistance (MDR) pathways during IUD in man.
ISSN:1567-2379
1567-2387
DOI:10.1007/s10735-011-9363-1