Expression and clinical significance of leptin, the functional receptor of leptin (OB-Rb) and HER-2 in non-small-cell lung cancer: a retrospective analysis

Background The human epidermal growth factor receptor 2 (HER-2) and leptin/OB-R system have been reported to be intertwined in several cancer types. However, limited research has been conducted with regard to this interaction in lung cancers. In this study, we investigated the relationship between t...

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Published in:Journal of cancer research and clinical oncology 2011-12, Vol.137 (12), p.1841-1848
Main Authors: Xu, Yan-Jie, Shao, Yong-Feng, Zhao, Xia, Geng, Yi-Ting, Wang, Kai, Yin, Yong-Mei
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic agents
Biological and medical sciences
Cancer Research
Carcinoma, Non-Small-Cell Lung - chemistry
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Female
Hematology
Humans
Immunohistochemistry
Internal Medicine
Leptin - analysis
Lung - chemistry
Lung cancer
Lung Neoplasms - chemistry
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Male
Medical prognosis
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Neoplasm Staging
Oncology
Original Paper
Pharmacology. Drug treatments
Pneumology
Prognosis
Proteins
Receptor, ErbB-2 - analysis
Receptors, Leptin - analysis
Retrospective Studies
Tumors of the respiratory system and mediastinum
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Summary:Background The human epidermal growth factor receptor 2 (HER-2) and leptin/OB-R system have been reported to be intertwined in several cancer types. However, limited research has been conducted with regard to this interaction in lung cancers. In this study, we investigated the relationship between the expression levels of these proteins and the development, progression and prognosis of non-small-cell lung cancer (NSCLC). Methods The expression of leptin, OB-Rb and HER-2 was evaluated in 100 NSCLC specimens by immunohistochemistry, with normal lung tissue as controls. The relationships between their expression levels and clinicopathological factors were evaluated by correlation analysis. Univariate and multivariate analyses were used to determine the associations between the expression levels of these proteins and the survival of NSCLC patients. Results Leptin was expressed in 71 and 25% ( P  
ISSN:0171-5216
1432-1335
DOI:10.1007/s00432-011-1054-5