Loading…
Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers
Rapid solubility screening in diverse supercritical fluids (SCFs) was carried out via multiple solubility chambers with a trapping device and online ultraviolet (UV) detection. With this device, it was possible to rapidly study the solubility variations of multiple components in a mixture. Results f...
Saved in:
Published in: | Chirality (New York, N.Y.) N.Y.), 2011, Vol.23 (Suppl. 1E), p.E65-E73 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c3997-62436f1141e8f41d560ff600d3d13d0a2c73e6b74c41d8dda3555ccde0d5e90f3 |
---|---|
cites | cdi_FETCH-LOGICAL-c3997-62436f1141e8f41d560ff600d3d13d0a2c73e6b74c41d8dda3555ccde0d5e90f3 |
container_end_page | E73 |
container_issue | Suppl. 1E |
container_start_page | E65 |
container_title | Chirality (New York, N.Y.) |
container_volume | 23 |
creator | Gahm, Kyung H. Huang, Ke Barnhart, Wesley W. Goetzinger, Wolfgang |
description | Rapid solubility screening in diverse supercritical fluids (SCFs) was carried out via multiple solubility chambers with a trapping device and online ultraviolet (UV) detection. With this device, it was possible to rapidly study the solubility variations of multiple components in a mixture. Results from solubility studies have been used to develop efficient supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) methods. After the investigation of solubilities of theophylline and caffeine in several neat organic solvents and SCFs, advantages of SFE over conventional organic solvent extraction were demonstrated with a model mixture of theophylline and caffeine. The highest solubility ratio of 1:40 (theophylline:caffeine) was observed in the SCF with 20% acetonitrile (MeCN), where a ratio of 1:11 was the highest in the neat organic solvents. A model mixture of theophylline:caffeine (85:15 w/w, caffeine as an impurity) was successfully purified by SFE by leveraging the highest solubility difference. The SCF with 20% MeCN selectively removed caffeine and left theophylline largely intact. Rapid SCF solubility screening was applied to development of SFE and SFC methods in a drug discovery environment. Two successful applications were demonstrated with proprietary Amgen compounds to either remove an achiral impurity before chiral purification or enhance chiral chromatographic throughput. Chirality, 2011. © 2011 Wiley Periodicals, Inc. |
doi_str_mv | 10.1002/chir.20967 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_901653163</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>901653163</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3997-62436f1141e8f41d560ff600d3d13d0a2c73e6b74c41d8dda3555ccde0d5e90f3</originalsourceid><addsrcrecordid>eNp90cFu1DAUBVALgei0sOEDkHcgpBQ7TpxkiQaYVowAQRHsLI_93BicONhO2_knPhJPp61YoK5s6Z53NxehZ5QcU0LK16q34bgkHW8eoAWtS1Jwxn88RAvSdl1BSFUeoMMYfxKSDaseo4OSNjz_6AL9eQsX4Pw0wJiwNzjOEwQVbLJKOmzcbDWGqxSkStaPWI76v0T1wQ8y-fMgp36LpzlYk-PrmwFS73XEc7TjOc4g--jdvLHOpi2OKgCMu-jSph4Ps0t2cvAvUb0cNhDiE_TISBfh6c17hL69f3e2PCnWn1anyzfrQrGuawpeVowbSisKramorjkxhhOimaZME1mqhgHfNJXKYau1ZHVdK6WB6Bo6YtgRerHvnYL_PUNMYrBRgXNyBD9H0RHKa0Y5y_LlvZI2VcWbtq3aTF_tqQo-xgBGTMEOMmwFJWK3o9jtKK53zPj5Te-8GUDf0dvhMqB7cGkdbO-pEsuT0y-3pcX-xsYEV3c3MvwSOW1q8f3jSnz4fNYu181XsWJ_AV7tveI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1744678848</pqid></control><display><type>article</type><title>Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers</title><source>Wiley</source><creator>Gahm, Kyung H. ; Huang, Ke ; Barnhart, Wesley W. ; Goetzinger, Wolfgang</creator><creatorcontrib>Gahm, Kyung H. ; Huang, Ke ; Barnhart, Wesley W. ; Goetzinger, Wolfgang</creatorcontrib><description>Rapid solubility screening in diverse supercritical fluids (SCFs) was carried out via multiple solubility chambers with a trapping device and online ultraviolet (UV) detection. With this device, it was possible to rapidly study the solubility variations of multiple components in a mixture. Results from solubility studies have been used to develop efficient supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) methods. After the investigation of solubilities of theophylline and caffeine in several neat organic solvents and SCFs, advantages of SFE over conventional organic solvent extraction were demonstrated with a model mixture of theophylline and caffeine. The highest solubility ratio of 1:40 (theophylline:caffeine) was observed in the SCF with 20% acetonitrile (MeCN), where a ratio of 1:11 was the highest in the neat organic solvents. A model mixture of theophylline:caffeine (85:15 w/w, caffeine as an impurity) was successfully purified by SFE by leveraging the highest solubility difference. The SCF with 20% MeCN selectively removed caffeine and left theophylline largely intact. Rapid SCF solubility screening was applied to development of SFE and SFC methods in a drug discovery environment. Two successful applications were demonstrated with proprietary Amgen compounds to either remove an achiral impurity before chiral purification or enhance chiral chromatographic throughput. Chirality, 2011. © 2011 Wiley Periodicals, Inc.</description><identifier>ISSN: 0899-0042</identifier><identifier>ISSN: 1520-636X</identifier><identifier>EISSN: 1520-636X</identifier><identifier>DOI: 10.1002/chir.20967</identifier><identifier>PMID: 21766341</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Caffeine ; Caffeine - chemistry ; Chemistry - methods ; Chromatography ; Chromatography - methods ; Chromatography, Supercritical Fluid - methods ; Devices ; Hydrogen Bonding ; Methanol - chemistry ; Pharmaceutical Preparations - chemistry ; Pharmaceutical Preparations - isolation & purification ; preparative chromatography ; Pressure ; SCF solubility ; Screening ; SFC chiral purification ; Solubility ; solubility ratio ; Solvent extraction ; Solvents - chemistry ; Stereoisomerism ; Supercritical fluids ; Temperature ; Theophylline ; Theophylline - chemistry</subject><ispartof>Chirality (New York, N.Y.), 2011, Vol.23 (Suppl. 1E), p.E65-E73</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3997-62436f1141e8f41d560ff600d3d13d0a2c73e6b74c41d8dda3555ccde0d5e90f3</citedby><cites>FETCH-LOGICAL-c3997-62436f1141e8f41d560ff600d3d13d0a2c73e6b74c41d8dda3555ccde0d5e90f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21766341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gahm, Kyung H.</creatorcontrib><creatorcontrib>Huang, Ke</creatorcontrib><creatorcontrib>Barnhart, Wesley W.</creatorcontrib><creatorcontrib>Goetzinger, Wolfgang</creatorcontrib><title>Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers</title><title>Chirality (New York, N.Y.)</title><addtitle>Chirality</addtitle><description>Rapid solubility screening in diverse supercritical fluids (SCFs) was carried out via multiple solubility chambers with a trapping device and online ultraviolet (UV) detection. With this device, it was possible to rapidly study the solubility variations of multiple components in a mixture. Results from solubility studies have been used to develop efficient supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) methods. After the investigation of solubilities of theophylline and caffeine in several neat organic solvents and SCFs, advantages of SFE over conventional organic solvent extraction were demonstrated with a model mixture of theophylline and caffeine. The highest solubility ratio of 1:40 (theophylline:caffeine) was observed in the SCF with 20% acetonitrile (MeCN), where a ratio of 1:11 was the highest in the neat organic solvents. A model mixture of theophylline:caffeine (85:15 w/w, caffeine as an impurity) was successfully purified by SFE by leveraging the highest solubility difference. The SCF with 20% MeCN selectively removed caffeine and left theophylline largely intact. Rapid SCF solubility screening was applied to development of SFE and SFC methods in a drug discovery environment. Two successful applications were demonstrated with proprietary Amgen compounds to either remove an achiral impurity before chiral purification or enhance chiral chromatographic throughput. Chirality, 2011. © 2011 Wiley Periodicals, Inc.</description><subject>Caffeine</subject><subject>Caffeine - chemistry</subject><subject>Chemistry - methods</subject><subject>Chromatography</subject><subject>Chromatography - methods</subject><subject>Chromatography, Supercritical Fluid - methods</subject><subject>Devices</subject><subject>Hydrogen Bonding</subject><subject>Methanol - chemistry</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Pharmaceutical Preparations - isolation & purification</subject><subject>preparative chromatography</subject><subject>Pressure</subject><subject>SCF solubility</subject><subject>Screening</subject><subject>SFC chiral purification</subject><subject>Solubility</subject><subject>solubility ratio</subject><subject>Solvent extraction</subject><subject>Solvents - chemistry</subject><subject>Stereoisomerism</subject><subject>Supercritical fluids</subject><subject>Temperature</subject><subject>Theophylline</subject><subject>Theophylline - chemistry</subject><issn>0899-0042</issn><issn>1520-636X</issn><issn>1520-636X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp90cFu1DAUBVALgei0sOEDkHcgpBQ7TpxkiQaYVowAQRHsLI_93BicONhO2_knPhJPp61YoK5s6Z53NxehZ5QcU0LK16q34bgkHW8eoAWtS1Jwxn88RAvSdl1BSFUeoMMYfxKSDaseo4OSNjz_6AL9eQsX4Pw0wJiwNzjOEwQVbLJKOmzcbDWGqxSkStaPWI76v0T1wQ8y-fMgp36LpzlYk-PrmwFS73XEc7TjOc4g--jdvLHOpi2OKgCMu-jSph4Ps0t2cvAvUb0cNhDiE_TISBfh6c17hL69f3e2PCnWn1anyzfrQrGuawpeVowbSisKramorjkxhhOimaZME1mqhgHfNJXKYau1ZHVdK6WB6Bo6YtgRerHvnYL_PUNMYrBRgXNyBD9H0RHKa0Y5y_LlvZI2VcWbtq3aTF_tqQo-xgBGTMEOMmwFJWK3o9jtKK53zPj5Te-8GUDf0dvhMqB7cGkdbO-pEsuT0y-3pcX-xsYEV3c3MvwSOW1q8f3jSnz4fNYu181XsWJ_AV7tveI</recordid><startdate>2011</startdate><enddate>2011</enddate><creator>Gahm, Kyung H.</creator><creator>Huang, Ke</creator><creator>Barnhart, Wesley W.</creator><creator>Goetzinger, Wolfgang</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>2011</creationdate><title>Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers</title><author>Gahm, Kyung H. ; Huang, Ke ; Barnhart, Wesley W. ; Goetzinger, Wolfgang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3997-62436f1141e8f41d560ff600d3d13d0a2c73e6b74c41d8dda3555ccde0d5e90f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Caffeine</topic><topic>Caffeine - chemistry</topic><topic>Chemistry - methods</topic><topic>Chromatography</topic><topic>Chromatography - methods</topic><topic>Chromatography, Supercritical Fluid - methods</topic><topic>Devices</topic><topic>Hydrogen Bonding</topic><topic>Methanol - chemistry</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Pharmaceutical Preparations - isolation & purification</topic><topic>preparative chromatography</topic><topic>Pressure</topic><topic>SCF solubility</topic><topic>Screening</topic><topic>SFC chiral purification</topic><topic>Solubility</topic><topic>solubility ratio</topic><topic>Solvent extraction</topic><topic>Solvents - chemistry</topic><topic>Stereoisomerism</topic><topic>Supercritical fluids</topic><topic>Temperature</topic><topic>Theophylline</topic><topic>Theophylline - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gahm, Kyung H.</creatorcontrib><creatorcontrib>Huang, Ke</creatorcontrib><creatorcontrib>Barnhart, Wesley W.</creatorcontrib><creatorcontrib>Goetzinger, Wolfgang</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Chirality (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gahm, Kyung H.</au><au>Huang, Ke</au><au>Barnhart, Wesley W.</au><au>Goetzinger, Wolfgang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers</atitle><jtitle>Chirality (New York, N.Y.)</jtitle><addtitle>Chirality</addtitle><date>2011</date><risdate>2011</risdate><volume>23</volume><issue>Suppl. 1E</issue><spage>E65</spage><epage>E73</epage><pages>E65-E73</pages><issn>0899-0042</issn><issn>1520-636X</issn><eissn>1520-636X</eissn><abstract>Rapid solubility screening in diverse supercritical fluids (SCFs) was carried out via multiple solubility chambers with a trapping device and online ultraviolet (UV) detection. With this device, it was possible to rapidly study the solubility variations of multiple components in a mixture. Results from solubility studies have been used to develop efficient supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) methods. After the investigation of solubilities of theophylline and caffeine in several neat organic solvents and SCFs, advantages of SFE over conventional organic solvent extraction were demonstrated with a model mixture of theophylline and caffeine. The highest solubility ratio of 1:40 (theophylline:caffeine) was observed in the SCF with 20% acetonitrile (MeCN), where a ratio of 1:11 was the highest in the neat organic solvents. A model mixture of theophylline:caffeine (85:15 w/w, caffeine as an impurity) was successfully purified by SFE by leveraging the highest solubility difference. The SCF with 20% MeCN selectively removed caffeine and left theophylline largely intact. Rapid SCF solubility screening was applied to development of SFE and SFC methods in a drug discovery environment. Two successful applications were demonstrated with proprietary Amgen compounds to either remove an achiral impurity before chiral purification or enhance chiral chromatographic throughput. Chirality, 2011. © 2011 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21766341</pmid><doi>10.1002/chir.20967</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0899-0042 |
ispartof | Chirality (New York, N.Y.), 2011, Vol.23 (Suppl. 1E), p.E65-E73 |
issn | 0899-0042 1520-636X 1520-636X |
language | eng |
recordid | cdi_proquest_miscellaneous_901653163 |
source | Wiley |
subjects | Caffeine Caffeine - chemistry Chemistry - methods Chromatography Chromatography - methods Chromatography, Supercritical Fluid - methods Devices Hydrogen Bonding Methanol - chemistry Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - isolation & purification preparative chromatography Pressure SCF solubility Screening SFC chiral purification Solubility solubility ratio Solvent extraction Solvents - chemistry Stereoisomerism Supercritical fluids Temperature Theophylline Theophylline - chemistry |
title | Development of supercritical fluid extraction and supercritical fluid chromatography purification methods using rapid solubility screening with multiple solubility chambers |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T20%3A05%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20supercritical%20fluid%20extraction%20and%20supercritical%20fluid%20chromatography%20purification%20methods%20using%20rapid%20solubility%20screening%20with%20multiple%20solubility%20chambers&rft.jtitle=Chirality%20(New%20York,%20N.Y.)&rft.au=Gahm,%20Kyung%20H.&rft.date=2011&rft.volume=23&rft.issue=Suppl.%201E&rft.spage=E65&rft.epage=E73&rft.pages=E65-E73&rft.issn=0899-0042&rft.eissn=1520-636X&rft_id=info:doi/10.1002/chir.20967&rft_dat=%3Cproquest_cross%3E901653163%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c3997-62436f1141e8f41d560ff600d3d13d0a2c73e6b74c41d8dda3555ccde0d5e90f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1744678848&rft_id=info:pmid/21766341&rfr_iscdi=true |