Preparation of acetylated chitosan sponges (chitin sponges)

Acetylated chitosan sponges (chitin sponges) were prepared according to acetylation time (25, 50, 75, and 100 h). As the acetylation time increased, the degree of acetylation increased, and a 75-h acetylation time produced the highest degree of acetylation (DA). The surface morphologies of samples w...

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Bibliographic Details
Published in:Journal of applied polymer science 2010-08, Vol.117 (3), p.1618-1623
Main Authors: Ko, Jung A, Kim, Bum Keun, Park, Hyun Jin
Format: Article
Language:English
Subjects:
Acetylation
Applied sciences
Biological and medical sciences
Chitin
Chitosan
degree of acetylation
Exact sciences and technology
Fibroblasts
In vitro testing
Medical sciences
Natural polymers
Physicochemistry of polymers
sponge
Sponges
Starch and polysaccharides
Surface chemistry
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Uptakes
wound healing
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Summary:Acetylated chitosan sponges (chitin sponges) were prepared according to acetylation time (25, 50, 75, and 100 h). As the acetylation time increased, the degree of acetylation increased, and a 75-h acetylation time produced the highest degree of acetylation (DA). The surface morphologies of samples were examined by scanning electron microscopy. Sponge samples were shown by a water uptake ability test to have higher water absorption abilities. An in vitro biodegradation test showed that sponges with a higher DA were more susceptible to lysozyme hydrolysis. Acetylated chitosan sponges were further shown by an in vitro fibroblast proliferation test to have a higher degree of cell viability on increasing the DA, with 75 h exhibiting the maximum effect. The results showed that the wound healing effect of chitosan sponges can be controlled by the DA.
ISSN:0021-8995
1097-4628
1097-4628
DOI:10.1002/app.32053