Nuclear magnetic resonance spectroscopy spectroscopic investigation of the aging mechanism of polyethylene terephthalate vascular prostheses

This article attempts to develop and prove a technique to determine the degradation of polyethylene terephthalate (PET) for vascular prostheses. The implicit goal is to be able to quantify the amount of degradation to study the effect of in vivo aging. Nuclear magnetic resonance spectroscopy (¹H-NMR...

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Bibliographic Details
Published in:Journal of applied polymer science 2009-09, Vol.113 (5), p.2813-2825
Main Authors: Chaouch, W, Dieval, F, Le Nouen, D, Defoin, A, Chakfe, N, Durand, B
Format: Article
Language:English
Subjects:
1H-NMR spectroscopy
aging
Application fields
Applied sciences
Biological and medical sciences
Biomedical materials
Degradation
Exact sciences and technology
In vivo tests
macromolecular weight
Medical sciences
polyethylene terephthalate
Polyethylene terephthalates
Polymer industry, paints, wood
Prostheses
Prosthetics
Spectroscopy
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgical implants
Technology of polymers
Technology. Biomaterials. Equipments
vascular prosthesis
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Summary:This article attempts to develop and prove a technique to determine the degradation of polyethylene terephthalate (PET) for vascular prostheses. The implicit goal is to be able to quantify the amount of degradation to study the effect of in vivo aging. Nuclear magnetic resonance spectroscopy (¹H-NMR) provides a comprehensive view of chemical macromolecular structures. Examination of a series of PET vascular prostheses showed significant chemical differences between the virgin prostheses and the explants collected after aging, especially for diethylene glycol and cyclic oligomers groups. Aging was investigated in terms of chemical scission of ester and ether linkages caused by hydrolytic reaction during the in vivo stay. Besides, we extended this ¹H-NMR technique to determine hydroxyl end-group concentrations and therefore the average number of macromolecular weight. To validate ¹H-NMR results, complementary techniques, the chemical titration method and the classical viscosimetric method, were used. The results showed an increase of hydroxyl end-group concentration and a decrease in the macromolecular weight for the explants.
ISSN:0021-8995
1097-4628
1097-4628
DOI:10.1002/app.30089