Organic-soluble chitosan/polyhydroxybutyrate ultrafine fibers as skin regeneration prepared by electrospinning

• Published in: Journal of applied polymer science 2010-12, Vol.118 (6), p.3619-3624
• Main Authors: Ma, Guiping, Yang, Dongzhi, Wang, Kemin, Han, Jing, Ding, Shumin, Song, Guoqiang, Nie, Jun
• Format: Article
• Language: English
• Subjects: Applied sciences; Biological and medical sciences; biological applications of polymers; biomaterials; Chitosan; Contact angle; Electrospinning; Exact sciences and technology; Fibers; Fibers and threads; Forms of application and semi-finished materials; Medical sciences; Polyhydroxybutyrate; Polymer industry, paints, wood; Regeneration; Reproduction; Scanning electron microscopy; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology of polymers; Technology. Biomaterials. Equipments; thermogravimetric analysis (TGA)
• ISSN: 0021-8995; 1097-4628; 1097-4628
• DOI: 10.1002/app.32671

In the present contribution, the ultrafine fiber membranes of polyhydroxybutyrate (PHB) and organic‐soluble chitosan(O‐CS) was prepared by electrospinning. The structure and thermal stability were studied by infrared (FTIR) and thermogravimetric analysis (TG). The surface properties of ultrafine fibers were estimated by contact angle measurements using water. The morphology was observed by scanning electron microscopy (SEM). The cytotoxicity assessment with mouse fibroblast cells (L929) was also investigated. Cell culture results showed that it benefits promoting the cell attachment and proliferation. The results showed it could be as tissue engineering for skin regeneration. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010