Vanadium bromoperoxidase from Delisea pulchra: enzyme-catalyzed formation of bromofuranone and attendant disruption of quorum sensing

Vanadium bromoperoxidase was isolated and cloned from the marine red alga Delisea pulchra. This enzyme catalyzes the bromolactonization of 4-pentynoic acid forming 5E-bromo-methylidenetetrahydro-2-furanone, a compound which is shown herein to inhibit quorum sensing in the engineered reporter strain,...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2011-11, Vol.47 (44), p.12086-12088
Main Authors: Sandy, Moriah, Carter-Franklin, Jayme N, Martin, Jessica D, Butler, Alison
Format: Article
Language:English
Subjects:
Agrobacterium tumefaciens - drug effects
Agrobacterium tumefaciens - physiology
beta-Galactosidase - metabolism
Furans - chemistry
Furans - pharmacology
Peroxidases - chemistry
Peroxidases - isolation & purification
Peroxidases - physiology
Quorum Sensing - drug effects
Rhodophyta - enzymology
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Summary:Vanadium bromoperoxidase was isolated and cloned from the marine red alga Delisea pulchra. This enzyme catalyzes the bromolactonization of 4-pentynoic acid forming 5E-bromo-methylidenetetrahydro-2-furanone, a compound which is shown herein to inhibit quorum sensing in the engineered reporter strain, Agrobacterium tumefaciens NTL4.
ISSN:1364-548X
DOI:10.1039/c1cc15605e