Structural stability studies in adhesion molecules—role of cation–π interactions

Cell adhesion molecules are important for their various roles in many cellular events and responses. In the present study, we have analyzed the roles played by cation–π interactions in the structural stability of adhesion molecules. These interactions are mainly formed by long-range contacts. The oc...

Full description

Saved in:
Bibliographic Details
Published in:Protoplasma 2011-10, Vol.248 (4), p.673-682
Main Authors: Sophiya, K, Anbarasu, Anand
Format: Article
Language:English
Subjects:
adhesion
Amino Acid Sequence
Amino Acids - chemistry
arginine
Biomedical and Life Sciences
Cations - chemistry
cell adhesion
Cell Adhesion Molecules - chemistry
Cell Biology
Computational Biology
Conserved Sequence
Databases, Protein
Life Sciences
lysine
Original Article
Plant Sciences
Protein Interaction Mapping
Protein Stability
Protein Structure, Secondary
proteins
Sequence Alignment
Sequence Analysis, Protein
Solvents - chemistry
Zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cell adhesion molecules are important for their various roles in many cellular events and responses. In the present study, we have analyzed the roles played by cation–π interactions in the structural stability of adhesion molecules. These interactions are mainly formed by long-range contacts. The occurrence of arginine is higher than lysine to form cation–π interactions. The secondary structure preferences of interacting residues are independent of amino acid class. Cation–π interactions might stabilize the interface between the terminus and core in this class of proteins. The results obtained in the present study will be useful in understanding the contribution of cation–π interactions to the overall stability of adhesion proteins.
ISSN:0033-183X
1615-6102
DOI:10.1007/s00709-010-0224-7