Novel Tripeptides with α-Glucosidase Inhibitory Activity Isolated from Silk Cocoon Hydrolysate

Active compounds with antidiabetic potential were isolated from silk peptide E5K6 by consecutive ultrafiltration and gel filtration using Biogel P-2 and RS-HPLC using a YMC-Pack Pro C18 column. The highest α-glucosidase inhibitory activity of silk peptide E5K6 resulted from fractions with MW

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2011-11, Vol.59 (21), p.11522-11525
Main Authors: Lee, Hyun Jung, Lee, Hyun-Sun, Choi, Jang Won, Ra, Kyung Soo, Kim, Jin-Man, Suh, Hyung Joo
Format: Article
Language:English
Subjects:
alpha-glucosidase
alpha-Glucosidases - analysis
amino acid sequences
Animals
Bioactive Constituents
Bombyx - chemistry
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Glycoside Hydrolase Inhibitors
high performance liquid chromatography
Humans
hydrolysates
Hydrolysis
Hypoglycemic Agents - chemistry
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
inhibitory concentration 50
Oligopeptides - chemistry
Oligopeptides - isolation & purification
Oligopeptides - pharmacology
silk
Silk - chemistry
tripeptides
ultrafiltration
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Description
Summary:Active compounds with antidiabetic potential were isolated from silk peptide E5K6 by consecutive ultrafiltration and gel filtration using Biogel P-2 and RS-HPLC using a YMC-Pack Pro C18 column. The highest α-glucosidase inhibitory activity of silk peptide E5K6 resulted from fractions with MW
ISSN:0021-8561
1520-5118
DOI:10.1021/jf202686m