Neural correlates of donepezil-induced cognitive improvement in patients with right hemisphere stroke: A pilot study

• Published in: Neuropsychological rehabilitation 2011-08, Vol.21 (4), p.502-514
• Main Authors: Chang, Won Hyuk, Park, Yun H., Ohn, Suk Hoon, Park, Chang-hyun, Lee, Peter K. W., Kim, Yun-Hee
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alzheimer's disease; Biological and medical sciences; Brain Mapping - methods; Brain Mapping - psychology; Cessation; Cognition Disorders - complications; Cognition Disorders - drug therapy; Cognition Disorders - physiopathology; Cognitive impairment; Donepezil; Female; Functional Laterality - physiology; functional MRI; Humans; Indans - therapeutic use; Induced; Male; Medical sciences; Middle Aged; Neural Pathways - drug effects; Neural Pathways - physiopathology; Neurology; Neuropharmacology; Neuropsychological Tests - statistics & numerical data; Nootropic Agents - therapeutic use; Pharmacology. Drug treatments; Pilot Projects; Piperidines - therapeutic use; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Recruitment; Stroke; Stroke - complications; Stroke - drug therapy; Stroke - physiopathology; Strokes; Vascular diseases and vascular malformations of the nervous system
• ISSN: 0960-2011; 1464-0694
• DOI: 10.1080/09602011.2011.582708

Donepezil has been proven effective in the treatment of Alzheimer's disease and vascular dementia. However, its effects on the cognitive neural network have not been fully investigated. The purpose of this study was to evaluate the effect of donepezil on reorganisation of the cognitive neural network in patients with post-stroke cognitive impairment using functional MRI (fMRI). Fourteen patients with stroke in the right hemisphere were enrolled. Participants were randomly assigned to the experimental or the control group. Donepezil (5 mg) or placebo was administered daily for four weeks. Cognitive function assessment was performed before and immediately after treatment, and repeated one month after cessation of treatment. fMRI was performed before and after treatment. Ten out of 14 patients (six in the experimental group, four in the control group) successfully completed all experimental processes. The experimental group showed significant improvements in the Mini-Mental Status Examination during the post-treatment evaluation and one-month follow-up compared to the pre-treatment evaluation (p