Postoperative Crohn's disease

More than three quarters of patients with Crohn's disease (CD) will require surgery. After resection, disease recurs postoperatively with a median time to second resection of about 10 years. Despite its importance, the postoperative period remains one of the most poorly understood clinical sett...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2005-08, Vol.11 (8), p.765-777
Main Authors: Penner, Robert M, Madsen, Karen L, Fedorak, Richard N
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Colectomy - adverse effects
Colectomy - methods
Colonoscopy
Crohn Disease - drug therapy
Crohn Disease - pathology
Crohn Disease - surgery
Crohn's disease
cytokines
Female
Humans
immunosuppressive agents
Immunosuppressive Agents - therapeutic use
Incidence
Male
Postoperative Complications - drug therapy
Postoperative Complications - pathology
Postoperative Complications - surgery
postoperative period
Probiotics - therapeutic use
Prognosis
Reoperation - statistics & numerical data
Risk Assessment
Secondary Prevention
Severity of Illness Index
surgery
Time Factors
Treatment Outcome
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Summary:More than three quarters of patients with Crohn's disease (CD) will require surgery. After resection, disease recurs postoperatively with a median time to second resection of about 10 years. Despite its importance, the postoperative period remains one of the most poorly understood clinical settings in the field. Postoperatively, CD may exhibit unique pathophysiologic features, but the current state of knowledge does not allow for identification of patients at risk for relapse, and leaves clinicians without guidance on optimal maintenance treatment. Therapies used as maintenance for CD in other settings may have different efficacies when used after surgery, and clinical research in patients requiring surgery is limited by the subset of patients available for study. Despite the many limitations in current knowledge of postoperative CD, it is an exciting field because new developments have improved patient care, and ongoing research has the potential for further gains.
ISSN:1078-0998
1536-4844
DOI:10.1097/01.MIB.0000171273.09757.f2