Contribution of genetic polymorphisms of stromal cell-derived factor-1 and its receptor, CXCR4, to the susceptibility and clinicopathologic development of oral cancer

Background. The aim of this study was to evaluate the relations of SDF‐1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR‐RFLP was used to measure SDF‐1‐3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age,...

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Published in:Head & neck 2009-10, Vol.31 (10), p.1282-1288
Main Authors: Teng, Ying-Hock, Liu, Te-Hsiung, Tseng, Hsien-Chun, Chung, Tsung-Te, Yeh, Chia-Ming, Li, Yu-Chiung, Ou, Yu-Hsiang, Lin, Long-Yau, Tsai, Hsiu-Ting, Yang, Shun-Fa
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - pathology
Cell Differentiation
Chemokine CXCL12 - genetics
CXCR4
Electrophoresis, Agar Gel
Female
Gene Expression Regulation, Neoplastic - genetics
Gene Frequency
Genetic Predisposition to Disease - genetics
Humans
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Mouth Neoplasms - genetics
Mouth Neoplasms - pathology
oral cancer
Otorhinolaryngology. Stomatology
polymorphism
Polymorphism, Genetic - genetics
Polymorphism, Restriction Fragment Length
Receptors, CXCR4 - genetics
SDF-1
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background. The aim of this study was to evaluate the relations of SDF‐1 and its receptor, CXCR4, gene variants on oral cancer risk. Methods. PCR‐RFLP was used to measure SDF‐1‐3′A and CXCR4 gene polymorphisms in 284 controls and 113 patients with oral cancer. Results. After being adjusted for age, individuals with A/G heterozygotes of SDF‐1 had a higher risk of 1.86‐fold to develop oral cancer when compared with those with G/G wild type homozygotes. Furthermore, patients with oral cancer with at least 1 mutant T allele of CXCR4 gene had a risk of 2.66‐fold to progress to stage III or IV. Conclusions. SDF‐1‐3′A gene polymorphism may be considered as a factor of increased susceptibility to oral cancer, and at least 1 mutated T allele of CXCR4 gene is associated with the development of stage III or IV and the induction of lymph‐node metastasis of oral cancer disease in Taiwanese. © 2009 Wiley Periodicals, Inc. Head Neck, 2009
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.21094