Interleukin‐10 polymorphisms in Spanish patients with IBD

Background: Inflammatory bowel disease (IBD) is considered a heterogeneous, complex polygenic disease where both genetic and environmental factors are involved in the development of the disease. Interleukin‐10 (IL‐10) is a regulatory cytokine that might play an important role in disease pathogenesis...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2005-08, Vol.11 (8), p.739-743
Main Authors: Fernandez, Laura, Martinez, Alfonso, Mendoza, Juan L, Urcelay, Elena, Fernandez‐Arquero, Miguel, Garcia‐Paredes, Julio, Diaz‐Rubio, Manuel, de la Concha, Emilio G
Format: Article
Language:English
Subjects:
Base Sequence
Case-Control Studies
Cohort Studies
Colitis, Ulcerative - epidemiology
Colitis, Ulcerative - genetics
Crohn Disease - epidemiology
Crohn Disease - genetics
Crohn's disease
Environmental factors
Female
Genetic Predisposition to Disease
Humans
Incidence
Inflammatory bowel diseases
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - genetics
Interleukin 10
Interleukin-10 - genetics
Male
Microsatellite Repeats
Microsatellites
Molecular Sequence Data
Odds Ratio
Polymerase Chain Reaction
Polymorphism, Genetic
polymorphisms
Probability
Promoters
Reference Values
Severity of Illness Index
Single-nucleotide polymorphism
Spain - epidemiology
Ulcerative colitis
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Summary:Background: Inflammatory bowel disease (IBD) is considered a heterogeneous, complex polygenic disease where both genetic and environmental factors are involved in the development of the disease. Interleukin‐10 (IL‐10) is a regulatory cytokine that might play an important role in disease pathogenesis. IL‐10 contains single nucleotide polymorphisms and 2 polymorphic microsatellites in the 5′‐flanking region. Our aim was to ascertain if any of these polymorphic markers is associated with IBD among Spanish patients. Methods: We genotyped 470 patients with IBD, 242 with ulcerative colitis and 228 with Crohn's disease (CD), and 572 ethnically matched controls for microsatellites IL‐10R and IL‐10G and 2 single nucleotide polymorphisms at positions ‐1082 and ‐819 in the proximal promoter of the gene. Results: IL‐10G14 microsatellite allele as well as ‐1082G allele were significantly increased in patients with CD. The combined presence of both alleles in 1 individual notably increased the risk to develop CD (P = 0.00006, odds ratio = 3.18). Conclusion: IL‐10 polymorphisms contribute to susceptibility to CD in Spanish population.
ISSN:1078-0998
1536-4844
DOI:10.1097/01.MIB.0000173457.64868.20