Critical appraisal of the current practice in murine TNBS‐induced colitis

There is no standard practice in the induction of colitis by 2,4,6‐trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6‐trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease a...

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Bibliographic Details
Published in:Inflammatory bowel diseases 2006-10, Vol.12 (10), p.995-999
Main Authors: te Velde, Anje A., Verstege, Marleen I., Hommes, Daniel W.
Format: Article
Language:English
Subjects:
Animal models
Animals
Colitis
Colitis - chemically induced
Disease Models, Animal
Drug Hypersensitivity
experimental colitis
Gene Expression Profiling - methods
Health Planning Guidelines
Humans
Hypersensitivity, Delayed - chemically induced
Inflammatory bowel diseases
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
sulfonic acid
TNBS colitis
Trinitrobenzenesulfonic Acid
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Summary:There is no standard practice in the induction of colitis by 2,4,6‐trinitrobenzene sulfonic acid. In this review the current practice in 2,4,6‐trinitrobenzene sulfonic acid colitis is studied using 20 recently published articles. We compare the different protocols, discuss the mechanism of disease and give recommendations for the future use of the model.
ISSN:1078-0998
1536-4844
DOI:10.1097/01.mib.0000227817.54969.5e