Platelet aggregation and adenosine triphosphate secretion in dogs with untreated multicentric lymphoma

Whole‐blood platelet aggregation and adenosine triphosphate secretion were measured in 15 dogs with untreated multicentric lymphoma and 10 normal control dogs to determine if dogs with lymphoma have altered platelet function. Dogs with quantitative platelet disorders (ie, thrombocytopenia or thrombo...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1999-07, Vol.13 (4), p.319-322
Main Authors: Thomas, J.S, Rogers, K.S
Format: Article
Language:English
Subjects:
adenosine diphosphate
adenosine triphosphate
Adenosine Triphosphate - metabolism
Animals
collagen
Dog Diseases - blood
Dog Diseases - physiopathology
Dogs
Female
lymphoma
Lymphoma - blood
Lymphoma - physiopathology
Lymphoma - veterinary
Male
Neoplasia
Platelet Aggregation
Platelet function
platelet-activating factor
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Summary:Whole‐blood platelet aggregation and adenosine triphosphate secretion were measured in 15 dogs with untreated multicentric lymphoma and 10 normal control dogs to determine if dogs with lymphoma have altered platelet function. Dogs with quantitative platelet disorders (ie, thrombocytopenia or thrombocytosis) or with clinical evidence of a bleeding disorder were excluded from the study. Platelets from affected dogs had significantly greater maximum aggregation than those from control dogs, suggesting that platelets from dogs with lymphoma are hyperactive. Platelet hyperactivity may play a role in the development of hemostatic disorders (eg, disseminated intravascular coagulation) or in tumor metastasis. Further investigation is needed to determine if modification of platelet function in patients with lymphoma affects disease progression or outcome.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.1999.tb02188.x