Loading…
Taste dysfunction in patients receiving radiotherapy
Background. Taste loss is a major cause of morbidity in patients undergoing head and neck irradiation. Methods. In a prospective study, 51 patients undergoing radical head and neck irradiation at the Tokyo University Hospital were assessed for taste loss. Taste ability was measured by the taste thre...
Saved in:
| Published in: | Head & neck 2006-06, Vol.28 (6), p.508-516 |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c5247-c0e069ba73553d8f7bfd347e7145c11c25423147498cb8d6fcb6de8b8fc2881f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c5247-c0e069ba73553d8f7bfd347e7145c11c25423147498cb8d6fcb6de8b8fc2881f3 |
| container_end_page | 516 |
| container_issue | 6 |
| container_start_page | 508 |
| container_title | Head & neck |
| container_volume | 28 |
| creator | Yamashita, Hideomi Nakagawa, Keiichi Tago, Masao Nakamura, Naoki Shiraishi, Kenshiro Eda, Momoe Nakata, Hiroki Nagamatsu, Nami Yokoyama, Rika Onimura, Mayuko Ohtomo, Kuni |
| description | Background.
Taste loss is a major cause of morbidity in patients undergoing head and neck irradiation.
Methods.
In a prospective study, 51 patients undergoing radical head and neck irradiation at the Tokyo University Hospital were assessed for taste loss. Taste ability was measured by the taste threshold for the four basic tastes (sweet, sour, salt, and bitter qualities) plus another taste of “umami” quality using a filter‐paper‐disc method in patients before, during, and after radiotherapy (RT).
Results.
All tastes declined on the fifth week after the start of RT and improved on the 11th week. Anatomic pathologic analyses in rats revealed that taste buds diminished completely on the sixth day after irradiation of 15 Gy in a single fraction, and the appearance of taste buds returned almost to the preirradiation state on the 28th day.
Conclusions.
The main cause of taste disorder resulting from RT was believed to be a disappearance of taste buds and not damage to the taste nerves. © 2006 Wiley Periodicals, Inc. Head Neck 28:508–516, 2006 |
| doi_str_mv | 10.1002/hed.20347 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_902335706</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>902335706</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5247-c0e069ba73553d8f7bfd347e7145c11c25423147498cb8d6fcb6de8b8fc2881f3</originalsourceid><addsrcrecordid>eNp1kLtOwzAUhi0EoqUw8AIoC0IMaX2NkxH1ioSKBEWMluPY1JAmxU6Bvj0pCWViOr-OvnPRB8A5gn0EIR4sddbHkFB-ALoIJjzc5cNdpiQkkNMOOPH-FUJIIoqPQQdFEUowZ11AF9JXOsi23mwKVdmyCGwRrGVldVH5wGml7YctXgInM1tWS-3kensKjozMvT5raw88TcaL4Sy8u5_eDm_uQsUw5aGCGkZJKjlhjGSx4anJ6sc0R5QphBRmFBNEOU1ilcZZZFQaZTpOY6NwHCNDeuCq2bt25ftG-0qsrFc6z2Why40XCcSEMA6jmrxuSOVK7502Yu3sSrqtQFDsHInakfhxVLMX7dZNuqq7e7KVUgOXLSC9krlxslDW_3E8pgklsOYGDfdpc739_6KYjUe_p8NmwtbSv_YT0r2JiBPOxPN8Kh6nc_YwhyMxId_OX4uI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>902335706</pqid></control><display><type>article</type><title>Taste dysfunction in patients receiving radiotherapy</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Yamashita, Hideomi ; Nakagawa, Keiichi ; Tago, Masao ; Nakamura, Naoki ; Shiraishi, Kenshiro ; Eda, Momoe ; Nakata, Hiroki ; Nagamatsu, Nami ; Yokoyama, Rika ; Onimura, Mayuko ; Ohtomo, Kuni</creator><creatorcontrib>Yamashita, Hideomi ; Nakagawa, Keiichi ; Tago, Masao ; Nakamura, Naoki ; Shiraishi, Kenshiro ; Eda, Momoe ; Nakata, Hiroki ; Nagamatsu, Nami ; Yokoyama, Rika ; Onimura, Mayuko ; Ohtomo, Kuni</creatorcontrib><description>Background.
Taste loss is a major cause of morbidity in patients undergoing head and neck irradiation.
Methods.
In a prospective study, 51 patients undergoing radical head and neck irradiation at the Tokyo University Hospital were assessed for taste loss. Taste ability was measured by the taste threshold for the four basic tastes (sweet, sour, salt, and bitter qualities) plus another taste of “umami” quality using a filter‐paper‐disc method in patients before, during, and after radiotherapy (RT).
Results.
All tastes declined on the fifth week after the start of RT and improved on the 11th week. Anatomic pathologic analyses in rats revealed that taste buds diminished completely on the sixth day after irradiation of 15 Gy in a single fraction, and the appearance of taste buds returned almost to the preirradiation state on the 28th day.
Conclusions.
The main cause of taste disorder resulting from RT was believed to be a disappearance of taste buds and not damage to the taste nerves. © 2006 Wiley Periodicals, Inc. Head Neck 28:508–516, 2006</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.20347</identifier><identifier>PMID: 16619275</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction ; Female ; filter-paper-disc ; head and neck cancer ; Head and Neck Neoplasms - radiotherapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Prospective Studies ; Radiation Dosage ; radiotherapy ; Radiotherapy - adverse effects ; taste bud ; Taste Buds - radiation effects ; taste changes ; Taste Disorders - diagnosis ; Taste Disorders - etiology ; Taste Disorders - physiopathology ; taste dysfunction ; Taste Threshold - radiation effects ; Tumors</subject><ispartof>Head & neck, 2006-06, Vol.28 (6), p.508-516</ispartof><rights>Copyright © 2006 Wiley Periodicals, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5247-c0e069ba73553d8f7bfd347e7145c11c25423147498cb8d6fcb6de8b8fc2881f3</citedby><cites>FETCH-LOGICAL-c5247-c0e069ba73553d8f7bfd347e7145c11c25423147498cb8d6fcb6de8b8fc2881f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17849430$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16619275$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamashita, Hideomi</creatorcontrib><creatorcontrib>Nakagawa, Keiichi</creatorcontrib><creatorcontrib>Tago, Masao</creatorcontrib><creatorcontrib>Nakamura, Naoki</creatorcontrib><creatorcontrib>Shiraishi, Kenshiro</creatorcontrib><creatorcontrib>Eda, Momoe</creatorcontrib><creatorcontrib>Nakata, Hiroki</creatorcontrib><creatorcontrib>Nagamatsu, Nami</creatorcontrib><creatorcontrib>Yokoyama, Rika</creatorcontrib><creatorcontrib>Onimura, Mayuko</creatorcontrib><creatorcontrib>Ohtomo, Kuni</creatorcontrib><title>Taste dysfunction in patients receiving radiotherapy</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Taste loss is a major cause of morbidity in patients undergoing head and neck irradiation.
Methods.
In a prospective study, 51 patients undergoing radical head and neck irradiation at the Tokyo University Hospital were assessed for taste loss. Taste ability was measured by the taste threshold for the four basic tastes (sweet, sour, salt, and bitter qualities) plus another taste of “umami” quality using a filter‐paper‐disc method in patients before, during, and after radiotherapy (RT).
Results.
All tastes declined on the fifth week after the start of RT and improved on the 11th week. Anatomic pathologic analyses in rats revealed that taste buds diminished completely on the sixth day after irradiation of 15 Gy in a single fraction, and the appearance of taste buds returned almost to the preirradiation state on the 28th day.
Conclusions.
The main cause of taste disorder resulting from RT was believed to be a disappearance of taste buds and not damage to the taste nerves. © 2006 Wiley Periodicals, Inc. Head Neck 28:508–516, 2006</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</subject><subject>Female</subject><subject>filter-paper-disc</subject><subject>head and neck cancer</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prospective Studies</subject><subject>Radiation Dosage</subject><subject>radiotherapy</subject><subject>Radiotherapy - adverse effects</subject><subject>taste bud</subject><subject>Taste Buds - radiation effects</subject><subject>taste changes</subject><subject>Taste Disorders - diagnosis</subject><subject>Taste Disorders - etiology</subject><subject>Taste Disorders - physiopathology</subject><subject>taste dysfunction</subject><subject>Taste Threshold - radiation effects</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOwzAUhi0EoqUw8AIoC0IMaX2NkxH1ioSKBEWMluPY1JAmxU6Bvj0pCWViOr-OvnPRB8A5gn0EIR4sddbHkFB-ALoIJjzc5cNdpiQkkNMOOPH-FUJIIoqPQQdFEUowZ11AF9JXOsi23mwKVdmyCGwRrGVldVH5wGml7YctXgInM1tWS-3kensKjozMvT5raw88TcaL4Sy8u5_eDm_uQsUw5aGCGkZJKjlhjGSx4anJ6sc0R5QphBRmFBNEOU1ilcZZZFQaZTpOY6NwHCNDeuCq2bt25ftG-0qsrFc6z2Why40XCcSEMA6jmrxuSOVK7502Yu3sSrqtQFDsHInakfhxVLMX7dZNuqq7e7KVUgOXLSC9krlxslDW_3E8pgklsOYGDfdpc739_6KYjUe_p8NmwtbSv_YT0r2JiBPOxPN8Kh6nc_YwhyMxId_OX4uI</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Yamashita, Hideomi</creator><creator>Nakagawa, Keiichi</creator><creator>Tago, Masao</creator><creator>Nakamura, Naoki</creator><creator>Shiraishi, Kenshiro</creator><creator>Eda, Momoe</creator><creator>Nakata, Hiroki</creator><creator>Nagamatsu, Nami</creator><creator>Yokoyama, Rika</creator><creator>Onimura, Mayuko</creator><creator>Ohtomo, Kuni</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>John Wiley & Sons</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>200606</creationdate><title>Taste dysfunction in patients receiving radiotherapy</title><author>Yamashita, Hideomi ; Nakagawa, Keiichi ; Tago, Masao ; Nakamura, Naoki ; Shiraishi, Kenshiro ; Eda, Momoe ; Nakata, Hiroki ; Nagamatsu, Nami ; Yokoyama, Rika ; Onimura, Mayuko ; Ohtomo, Kuni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5247-c0e069ba73553d8f7bfd347e7145c11c25423147498cb8d6fcb6de8b8fc2881f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction</topic><topic>Female</topic><topic>filter-paper-disc</topic><topic>head and neck cancer</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prospective Studies</topic><topic>Radiation Dosage</topic><topic>radiotherapy</topic><topic>Radiotherapy - adverse effects</topic><topic>taste bud</topic><topic>Taste Buds - radiation effects</topic><topic>taste changes</topic><topic>Taste Disorders - diagnosis</topic><topic>Taste Disorders - etiology</topic><topic>Taste Disorders - physiopathology</topic><topic>taste dysfunction</topic><topic>Taste Threshold - radiation effects</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamashita, Hideomi</creatorcontrib><creatorcontrib>Nakagawa, Keiichi</creatorcontrib><creatorcontrib>Tago, Masao</creatorcontrib><creatorcontrib>Nakamura, Naoki</creatorcontrib><creatorcontrib>Shiraishi, Kenshiro</creatorcontrib><creatorcontrib>Eda, Momoe</creatorcontrib><creatorcontrib>Nakata, Hiroki</creatorcontrib><creatorcontrib>Nagamatsu, Nami</creatorcontrib><creatorcontrib>Yokoyama, Rika</creatorcontrib><creatorcontrib>Onimura, Mayuko</creatorcontrib><creatorcontrib>Ohtomo, Kuni</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamashita, Hideomi</au><au>Nakagawa, Keiichi</au><au>Tago, Masao</au><au>Nakamura, Naoki</au><au>Shiraishi, Kenshiro</au><au>Eda, Momoe</au><au>Nakata, Hiroki</au><au>Nagamatsu, Nami</au><au>Yokoyama, Rika</au><au>Onimura, Mayuko</au><au>Ohtomo, Kuni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taste dysfunction in patients receiving radiotherapy</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2006-06</date><risdate>2006</risdate><volume>28</volume><issue>6</issue><spage>508</spage><epage>516</epage><pages>508-516</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Taste loss is a major cause of morbidity in patients undergoing head and neck irradiation.
Methods.
In a prospective study, 51 patients undergoing radical head and neck irradiation at the Tokyo University Hospital were assessed for taste loss. Taste ability was measured by the taste threshold for the four basic tastes (sweet, sour, salt, and bitter qualities) plus another taste of “umami” quality using a filter‐paper‐disc method in patients before, during, and after radiotherapy (RT).
Results.
All tastes declined on the fifth week after the start of RT and improved on the 11th week. Anatomic pathologic analyses in rats revealed that taste buds diminished completely on the sixth day after irradiation of 15 Gy in a single fraction, and the appearance of taste buds returned almost to the preirradiation state on the 28th day.
Conclusions.
The main cause of taste disorder resulting from RT was believed to be a disappearance of taste buds and not damage to the taste nerves. © 2006 Wiley Periodicals, Inc. Head Neck 28:508–516, 2006</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16619275</pmid><doi>10.1002/hed.20347</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-3074 |
| ispartof | Head & neck, 2006-06, Vol.28 (6), p.508-516 |
| issn | 1043-3074 1097-0347 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_902335706 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction Female filter-paper-disc head and neck cancer Head and Neck Neoplasms - radiotherapy Humans Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Prospective Studies Radiation Dosage radiotherapy Radiotherapy - adverse effects taste bud Taste Buds - radiation effects taste changes Taste Disorders - diagnosis Taste Disorders - etiology Taste Disorders - physiopathology taste dysfunction Taste Threshold - radiation effects Tumors |
| title | Taste dysfunction in patients receiving radiotherapy |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T11%3A52%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Taste%20dysfunction%20in%20patients%20receiving%20radiotherapy&rft.jtitle=Head%20&%20neck&rft.au=Yamashita,%20Hideomi&rft.date=2006-06&rft.volume=28&rft.issue=6&rft.spage=508&rft.epage=516&rft.pages=508-516&rft.issn=1043-3074&rft.eissn=1097-0347&rft_id=info:doi/10.1002/hed.20347&rft_dat=%3Cproquest_cross%3E902335706%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5247-c0e069ba73553d8f7bfd347e7145c11c25423147498cb8d6fcb6de8b8fc2881f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=902335706&rft_id=info:pmid/16619275&rfr_iscdi=true |