Vincristine therapy for mast cell tumors in dogs

Twenty‐seven dogs with naturally occurring mast cell tumors were treated with weekly IV injections of vincristine (0.75 mg/m2) for 4 treatments. Two dogs (7%) had a partial response. Nine dogs (32%) had treatment stopped prematurely because of toxicity or a perceived deterioration in their quality o...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1997-11, Vol.11 (6), p.375-378
Main Authors: McCaw, D.L, Miller, M.A, Bergman, P.J, Withrow, S.J, Moore, A.S, Knapp, D.W, Fowler, D, Johnson, J.C
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
ALCALOIDE
ALCALOIDES
ALKALOIDS
Animals
ANTINEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - therapeutic use
CELULAS FIBROSAS
CHIEN
Dog Diseases
DOGS
DRUG THERAPY
Female
INDOL
INDOLES
Injections, Intravenous
Male
MAST CELLS
Mast-Cell Sarcoma - drug therapy
Mast-Cell Sarcoma - pathology
Mast-Cell Sarcoma - veterinary
MASTOCYTE
MEDICAMENT CYTOSTATIQUE
NEOPLASMAS
NEOPLASME
NEOPLASMS
Orchiectomy
Ovariectomy
PERRO
TERAPEUTICA MEDICAMENTOSA
THERAPEUTIQUE MEDICAMENTEUSE
Vincristine - administration & dosage
Vincristine - therapeutic use
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Description
Summary:Twenty‐seven dogs with naturally occurring mast cell tumors were treated with weekly IV injections of vincristine (0.75 mg/m2) for 4 treatments. Two dogs (7%) had a partial response. Nine dogs (32%) had treatment stopped prematurely because of toxicity or a perceived deterioration in their quality of life. We conclude that vincristine is ineffective as a sole treatment for measurable mast cell tumors in dogs and produces an undesirable number of adverse reactions.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.1997.tb00484.x