Lupus-type anticoagulant in a dog with hemolysis and thrombosis

A circulating anticoagulant was detected in a 2‐year‐old Chesapeake Bay Retriever with hemolytic anemia, nephrotic syndrome, thrombocytopenia, polyarthropathy, and pulmonary thromboembolism. A persistent prolongation of the activated partial thromboplastin time (aPTT) was detected, and it did not co...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1994-01, Vol.8 (1), p.57-61
Main Authors: Stone, M.S, Johnstone, I.B, Brooks, M, Bollinger, T.K, Cotter, S.M
Format: Article
Language:English
Subjects:
ANAEMIA
ANEMIA
Anemia, Hemolytic - blood
Anemia, Hemolytic - complications
Anemia, Hemolytic - veterinary
ANEMIE
Animals
ANTICOAGULANT
ANTICOAGULANTES
ANTICOAGULANTS
CHIEN
COMPLICATIONS
Dog Diseases - blood
DOGS
Female
HAEMOLYSIS
HEMOLISIS
HEMOLYSE
Lupus Coagulation Inhibitor - blood
PATHOGENESE
PATHOGENESIS
PATOGENESIS
PERRO
PULMONARY THROMBOEMBOLISM
Thromboembolism - blood
Thromboembolism - complications
Thromboembolism - veterinary
THROMBOSE
THROMBOSIS
TROMBOSIS
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Description
Summary:A circulating anticoagulant was detected in a 2‐year‐old Chesapeake Bay Retriever with hemolytic anemia, nephrotic syndrome, thrombocytopenia, polyarthropathy, and pulmonary thromboembolism. A persistent prolongation of the activated partial thromboplastin time (aPTT) was detected, and it did not correct with repeated administration of fresh frozen plasma. The aPTT was still prolonged, with a 1:1 mixture of patient's plasma and normal dog plasma in vitro, suggesting the presence of a circulating inhibitor. Results of assays to characterize the inhibitor were compatible with those described for the lupus anticoagulant in human patients with systemic lupus erythematosus. Paradoxically, patients having the lupus anticoagulant are at increased risk for thrombosis. Pulmonary thromboembolism has been described as a frequent complication of immune‐mediated hemolytic anemia in the dog, and the presence of a circulating anticoagulant should be considered as a potential mechanism.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.1994.tb03197.x