Penicillium aurantiogriseum Dierckx 1901: Producer of Diketopiperazine Alkaloids (Roquefortine and 3,12-Dihydroroquefortine), Isolated from Permafrost

Secondary metabolites of three strains of Penicillium aurantiogriseumisolated from permafrost sediments were identified. It was found that these fungi synthesized the diketopiperazine alkaloids roquefortine and 3,12-dihydroroquefortine. The strain VKM FW-766 synthesized alkaloids in the course of ce...

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Bibliographic Details
Published in:Applied biochemistry and microbiology 2003-07, Vol.39 (4), p.393-397
Main Authors: Kozlovsky, A G, Zhelifonova, V P, Adanin, V M, Antipova, T V, Ozerskaya, S M, Ivanushkina, N E, Grafe, U
Format: Article
Language:English
Subjects:
Bacteria
Metabolites
Microbiology
Penicillium
Permafrost
Secondary metabolites
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Summary:Secondary metabolites of three strains of Penicillium aurantiogriseumisolated from permafrost sediments were identified. It was found that these fungi synthesized the diketopiperazine alkaloids roquefortine and 3,12-dihydroroquefortine. The strain VKM FW-766 synthesized alkaloids in the course of certain growth-related processes. When the strain was grown on a mineral medium, the time courses of the roquefortine and 3,12-dihydroroquefortine concentrations were characterized by biphasic curves.[PUBLICATION ABSTRACT]
ISSN:0003-6838
1608-3024
DOI:10.1023/A:1024572602458