Middle-Latency Auditory-Evoked Potential in Acepromazine-Sedated Dogs

The middle‐latency auditory‐evoked potential (MLAEP) has been investigated as means of monitoring anesthesia in dogs. The goals of this study were to develop a technique to record MLAEPs in awake dogs and to determine the effects of sedation. The MLAEP was recorded in 12 dogs with and without sedati...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2004-03, Vol.18 (2), p.196-200
Main Authors: Murrell, Joanna C., de Groot, H.N.M., Haagen, A.J. Venker-van, van den Brom, W.E., Hellebrekers, L.J.
Format: Article
Language:English
Subjects:
Acepromazine - administration & dosage
Acepromazine - pharmacology
Acoustic Stimulation - instrumentation
Acoustic Stimulation - veterinary
Anesthesia - veterinary
Animals
Awake
Awareness - physiology
Dogs - physiology
Evoked Potentials, Auditory, Brain Stem - drug effects
Female
Hypnotics and Sedatives - administration & dosage
Hypnotics and Sedatives - pharmacology
Injections, Intramuscular - veterinary
Male
Monitor
Neurophysiologic
Sedation
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Summary:The middle‐latency auditory‐evoked potential (MLAEP) has been investigated as means of monitoring anesthesia in dogs. The goals of this study were to develop a technique to record MLAEPs in awake dogs and to determine the effects of sedation. The MLAEP was recorded in 12 dogs with and without sedation with acepromazine. Three needle electrodes were inserted SC. Click stimuli were delivered biaurally. Signal acquisition, averaging, and analysis were performed by software developed in‐house. Signals were recorded for 128 milliseconds, and the responses to 1,024 stimuli were averaged. The waveforms from 10 recordings were averaged, and the amplitudes and latencies of peaks that could be consistently identified were measured. Data measured were compared by means of a paired 2‐sided Student's t‐test. Interpretable MLAEPs were recorded in 10 of the 12 dogs. Three peaks were consistently identified (Pa, Nb, and Pb). The latencies of these peaks were significantly (P = .032, .035, and .028, respectively) shorter in awake (mean ± SD milliseconds) (Pa = 18.85 ± 1.36, Nb = 30.50 ± 3.55, and Pb = 47.70 ± 5.53) than in sedated (Pa = 22.40 ± 3.88, Nb = 35.75 ± 6.77, and Pb = 55.30 ± 10.55) dogs. The Pb amplitude was not significantly different (2.51 ± 1.30 sV awake and 2.19 ± 1.10 μV sedated). This study demonstrates that acepromazine sedation causes changes in MLAEP
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2004.tb00160.x