Identification of AGR2 protein, a novel potential cancer marker, using proteomics technologies

A comparative analysis of the proteins in prostate tissues of the patients operated for hyperplasia (n = 7) or cancer (n = 5) was performed aiming to search for protein diagnostic markers. Differences in several minor proteins were detected using two-dimensional electrophoresis according to O'F...

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Bibliographic Details
Published in:Applied biochemistry and microbiology 2006-07, Vol.42 (4), p.424-427
Main Authors: Kovalyov, LI, Shishkin, S S, Khasigov, P Z, Dzeranov, N K, Kazachenko, A V, Kovalyova, MA, Toropygin, IYu, Mamykina, S V
Format: Article
Language:English
Subjects:
Cancer
Comparative analysis
Mass spectrometry
Medical research
Molecular weight
Prostate cancer
Proteins
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Summary:A comparative analysis of the proteins in prostate tissues of the patients operated for hyperplasia (n = 7) or cancer (n = 5) was performed aiming to search for protein diagnostic markers. Differences in several minor proteins were detected using two-dimensional electrophoresis according to O'Farrel; among them, an additional protein with a molecular weight of 19 kDa and an isoelectric point of 9.0 was observed in four of the cancer cases. Mass spectrometry allowed this protein to be identified as the androgen-induced secreted protein AGR2. The possibility of using AGR2 as a diagnostic marker of prostate cancer is discussed.
ISSN:0003-6838
1608-3024
DOI:10.1134/S0003683806040156