Combined Transcranial Direct Current Stimulation and Robot-Assisted Arm Training in Subacute Stroke Patients: An Exploratory, Randomized Multicenter Trial

Background. No rehabilitation intervention has effectively improved functional use of the arm and hand in patients with severe upper limb paresis after stroke. Pilot studies suggest the potential for transcranial direct current stimulation and bilateral robotic training to enhance gains. Objective....

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Bibliographic Details
Published in:Neurorehabilitation and neural repair 2011-11, Vol.25 (9), p.838-846
Main Authors: Hesse, Stefan, Waldner, Andreas, Mehrholz, Jan, Tomelleri, Christopher, Pohl, Michael, Werner, Cordula
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Arm
Clinical trials
Cortex
Double-Blind Method
Electric Stimulation Therapy - instrumentation
Electric Stimulation Therapy - methods
Electrodes
Exercise Therapy - instrumentation
Exercise Therapy - methods
Female
Hand
Hands
Humans
Ischemia
Limbs
Male
Middle Aged
Motor control
Motor task performance
Movement
Neurology
Paresis
Paresis - etiology
Paresis - physiopathology
Paresis - rehabilitation
Patients
Rehabilitation
Repetition
robotics
Robotics - instrumentation
Robotics - methods
robots
Stimuli
Stroke
Stroke - complications
Stroke - physiopathology
Stroke Rehabilitation
Transcranial Magnetic Stimulation - instrumentation
Transcranial Magnetic Stimulation - methods
Young Adult
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Description
Summary:Background. No rehabilitation intervention has effectively improved functional use of the arm and hand in patients with severe upper limb paresis after stroke. Pilot studies suggest the potential for transcranial direct current stimulation and bilateral robotic training to enhance gains. Objective. In a double-blind, randomized trial the combination of these interventions was tested. Methods. This study randomized 96 patients with an ischemic supratentorial lesion of 3 to 8 weeks’ duration with severe impairment of motor control with a Fugl-Meyer score (FMS) for the upper limb
ISSN:1545-9683
1552-6844
DOI:10.1177/1545968311413906