Parathyroid hormone–related peptide as a cause of hypercalcemia in squamous cell carcinoma of the head and neck: A case presentation and subject review

Background. Serum levels of parathyroid hormone–related peptide (PTHrP) can be elevated with malignancy and cause hypercalcemia, which has been associated with a poor prognosis. Methods. We present a case of supraglottic squamous cell carcinoma with elevated serum PTHrP and hypercalcemia. The patien...

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Bibliographic Details
Published in:Head & neck 2004-04, Vol.26 (4), p.382-384
Main Authors: Brawner, J. Travis, Zitsch, Robert P.
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - complications
Carcinoma, Squamous Cell - surgery
head and neck cancer
Humans
hypercalcemia
Hypercalcemia - blood
Hypercalcemia - etiology
Laryngeal Neoplasms - blood
Laryngeal Neoplasms - complications
Laryngeal Neoplasms - surgery
Laryngectomy
Male
malignancy
Medical sciences
Neck Dissection - methods
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Parathyroid Hormone-Related Protein - blood
parathyroid hormone–related protein
Peptide Hormones - blood
squamous cell carcinoma
Tumors
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Summary:Background. Serum levels of parathyroid hormone–related peptide (PTHrP) can be elevated with malignancy and cause hypercalcemia, which has been associated with a poor prognosis. Methods. We present a case of supraglottic squamous cell carcinoma with elevated serum PTHrP and hypercalcemia. The patient was acutely managed with intravenous fluids, furosemide, and zoledronic acid and then underwent a total laryngectomy and modified radical neck dissection. Results. The patient remains disease free and normocalcemic. Conclusion. Curative treatment for patients with head and neck cancer should not be withheld solely on the basis of humoral hypecalcemia of malignancy. © 2004 Wiley Periodicals, Inc. Head Neck 26: 382–384, 2004
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.20003