Radioguided surgery in primary hyperparathyroidism

Surgical neck exploration is usually made in primary hyperparathyroidism (PHPT). Localization of the adenoma or detection of hyperplasia may reduce the operation period and limit the extent of the surgery. In this study the effficacy of preoperative Tc-99m MIBI scintigraphy and intraoperative gamma...

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Bibliographic Details
Published in:Annals of nuclear medicine 2002-07, Vol.16 (5), p.359-362
Main Authors: Küçük, N O, Arican, P, Koçak, S, Aras, G
Format: Article
Language:English
Subjects:
Adenoma
Adenoma - complications
Adenoma - diagnostic imaging
Adenoma - surgery
Adult
Exploration
Female
Gamma Cameras
Humans
Hyperparathyroidism
Hyperparathyroidism - diagnostic imaging
Hyperparathyroidism - etiology
Hyperparathyroidism - surgery
Hyperplasia
Intraoperative Care - methods
Intraoperative Period - methods
Localization
Male
Middle Aged
Parathyroid
Parathyroid Neoplasms - complications
Parathyroid Neoplasms - diagnostic imaging
Parathyroid Neoplasms - surgery
Parathyroidectomy
Quality Control
Radionuclide Imaging
Radiopharmaceuticals
Scintigraphy
Sensitivity and Specificity
Surgery
Surgical outcomes
Technetium Tc 99m Sestamibi
Treatment Outcome
Tumors
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Summary:Surgical neck exploration is usually made in primary hyperparathyroidism (PHPT). Localization of the adenoma or detection of hyperplasia may reduce the operation period and limit the extent of the surgery. In this study the effficacy of preoperative Tc-99m MIBI scintigraphy and intraoperative gamma probe was evaluated. Six patients with PHPT had preoperative Tc-99m MIBI parathyroid scintigraphy and intraoperative gamma probe (IGP) was used in surgical neck exploration. Parathyroid adenoma was observed in 2/6 patients on scintigraphy in the right retroclavicular region and the left lobe of the thyroid. Both of them were clearly detected by IGP during the surgery and easily removed by the surgeon in a short time (35 min) with a small incision. Pathologic examination confirmed the parathyroid adenoma. No abnormal MIBI uptake was not observed in scintigraphy in 4/6 patients. Subtotal parathyroidectomy was performed in these patients. Preoperative Tc-99m MIBI scintigraphy and the use of IGP may limit the exploration and also the operation time and reduce surgical complications.
ISSN:0914-7187
1864-6433
DOI:10.1007/BF02988622