Vincristine Impairs Platelet Aggregation in Dogs with Lymphoma

Platelet aggregation before and after administration of 0.5 mg/m2 of vincristine (VCR) was evaluated in 7 dogs with spontaneously occuring lymphoma. Aggregation on platelet‐rich plasma separated from blood collected in 3.8% sodium citrate was performed using adenosine diphosphate (ADP), arachidonic...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2000-01, Vol.14 (1), p.81-85
Main Authors: Grau-Bassas, Enrique Rodriguez, Kociba, Gary J., Couto, C. Guillermo
Format: Article
Language:English
Subjects:
Adenosine Diphosphate - metabolism
Animals
Antineoplastic Agents, Phytogenic - adverse effects
Antineoplastic Agents, Phytogenic - therapeutic use
Arachidonic Acid - metabolism
Cancer
Collagen - metabolism
Dog Diseases - drug therapy
Dogs
Lymphoma - drug therapy
Lymphoma - veterinary
Plant alkaloids
Platelet Aggregation - drug effects
Platelet dysfunction
Vincristine - adverse effects
Vincristine - therapeutic use
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Summary:Platelet aggregation before and after administration of 0.5 mg/m2 of vincristine (VCR) was evaluated in 7 dogs with spontaneously occuring lymphoma. Aggregation on platelet‐rich plasma separated from blood collected in 3.8% sodium citrate was performed using adenosine diphosphate (ADP), arachidonic acid (AA), and collagen (COL) as agonists. The slope for aggregation in response to ADP was significantly lower after administration of VCR (P= .032). Maximal aggregation after administration of VCR was significantly lower in response to ADP, COL, and AA (P= .03, P= .04, and P= .03, respectively).
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2000.tb01503.x