MOPP Chemotherapy for Treatment of Resistant Lymphoma in Dogs: A Retrospective Study of 117 Cases (1989-2000)

The purpose of this retrospective study was to evaluate the efficacy and toxicity of the MOPP chemotherapy protocol (mechlor‐ethamine, vincristine, procarbazine, and prednisone) as a rescue regimen in dogs with lymphoma. One hundred seventeen dogs that had resistance to previously administered chemo...

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Published in:Journal of veterinary internal medicine 2002-09, Vol.16 (5), p.576-580
Main Authors: Rassnick, Kenneth M., Mauldin, Glenna E., Al-Sarraf, Renee, Mauldin, G. Neal, Moore, Antony S., Mooney, Samantha C.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Canine
Dog Diseases - drug therapy
Dogs
Drug Resistance, Neoplasm
Female
Lymphoma - drug therapy
Lymphoma - veterinary
Lymphosarcoma
Male
Mechlorethamine - adverse effects
Mechlorethamine - therapeutic use
Prednisone - adverse effects
Prednisone - therapeutic use
Procarbazine - adverse effects
Procarbazine - therapeutic use
Remission Induction
Rescue
Retrospective Studies
Treatment Outcome
Vincristine - adverse effects
Vincristine - therapeutic use
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Summary:The purpose of this retrospective study was to evaluate the efficacy and toxicity of the MOPP chemotherapy protocol (mechlor‐ethamine, vincristine, procarbazine, and prednisone) as a rescue regimen in dogs with lymphoma. One hundred seventeen dogs that had resistance to previously administered chemotherapy were evaluated. Before treatment with MOPP, all dogs received a median of 6 chemotherapy drugs for a median duration of 213 days. Thirty‐one percent (36 of 117) had a complete response (CR) to MOPP for a median of 63 days, and 34% (40 of 117) had a partial response (PR) for a median of 47 days. Sixteen percent (19 of 117) had stable disease (SD) for a median of 33 days. Predictors for response to MOPP were not identified. Gastrointestinal (GI) toxicity occurred in 28% (33 of 117) of the dogs, and 13% (15 dogs) required hospitalization. Five dogs developed septicemia, and 2 died as a result. MOPP was an effective treatment for dogs with resistant lymphoma and was well tolerated by the majority of affected dogs.
ISSN:0891-6640
1939-1676
DOI:10.1111/j.1939-1676.2002.tb02390.x