Variability of a diterpene with potential anti-HIV activity isolated from the Brazilian brown alga Dictyota menstrualis

This study evaluated the variability in the production of an HIV-1 antiviral diterpene in individuals of Dictyota menstrualis throughout reproductive stages. The brown alga Dictyota has an isomorphic biphasic life cycle. The quantification of the active principle by GC–FID indicated a greater produc...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied phycology 2011, Vol.23 (5), p.873-876
Main Authors: Cavalcanti, Diana Negrão, de Oliveira, Meire-Anne Rezende, De-Paula, Joel Campos, Barbosa, Leandro Silva, Fogel, Tamara, Pinto, Marcelo Alves, de Palmer Paixão, Izabel Christina Nunes, Teixeira, Valéria Laneuville
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Dictyota
Dictyota menstrualis
drugs
Ecology
Freshwater & Marine Ecology
gametophytes
Human immunodeficiency virus
Human immunodeficiency virus 1
Life Sciences
Plant Physiology
Plant Sciences
sporophytes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study evaluated the variability in the production of an HIV-1 antiviral diterpene in individuals of Dictyota menstrualis throughout reproductive stages. The brown alga Dictyota has an isomorphic biphasic life cycle. The quantification of the active principle by GC–FID indicated a greater production of the diterpene in the female gametophytic phase (42.11 ppm). However, these individuals had the highest variation between individuals (standard deviation of 68.20 ppm in the range from 0.39 to 227 ppm). Sporophytic individuals showed less variability. This variability in the production of the antiviral diterpene is important to the development of future antiviral drugs.
ISSN:0921-8971
1573-5176
DOI:10.1007/s10811-010-9601-z