Variability of a diterpene with potential anti-HIV activity isolated from the Brazilian brown alga Dictyota menstrualis

This study evaluated the variability in the production of an HIV-1 antiviral diterpene in individuals of Dictyota menstrualis throughout reproductive stages. The brown alga Dictyota has an isomorphic biphasic life cycle. The quantification of the active principle by GC–FID indicated a greater produc...

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Published in:Journal of applied phycology 2011, Vol.23 (5), p.873-876
Main Authors: Cavalcanti, Diana Negrão, de Oliveira, Meire-Anne Rezende, De-Paula, Joel Campos, Barbosa, Leandro Silva, Fogel, Tamara, Pinto, Marcelo Alves, de Palmer Paixão, Izabel Christina Nunes, Teixeira, Valéria Laneuville
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Dictyota
Dictyota menstrualis
drugs
Ecology
Freshwater & Marine Ecology
gametophytes
Human immunodeficiency virus
Human immunodeficiency virus 1
Life Sciences
Plant Physiology
Plant Sciences
sporophytes
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cited_by cdi_FETCH-LOGICAL-c368t-8d4dae771a482ebeec84d93eec0e76bf559c947150b11587ffe92741abc2754a3
cites cdi_FETCH-LOGICAL-c368t-8d4dae771a482ebeec84d93eec0e76bf559c947150b11587ffe92741abc2754a3
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container_issue 5
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container_title Journal of applied phycology
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creator Cavalcanti, Diana Negrão
de Oliveira, Meire-Anne Rezende
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Teixeira, Valéria Laneuville
description This study evaluated the variability in the production of an HIV-1 antiviral diterpene in individuals of Dictyota menstrualis throughout reproductive stages. The brown alga Dictyota has an isomorphic biphasic life cycle. The quantification of the active principle by GC–FID indicated a greater production of the diterpene in the female gametophytic phase (42.11 ppm). However, these individuals had the highest variation between individuals (standard deviation of 68.20 ppm in the range from 0.39 to 227 ppm). Sporophytic individuals showed less variability. This variability in the production of the antiviral diterpene is important to the development of future antiviral drugs.
doi_str_mv 10.1007/s10811-010-9601-z
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source Springer Nature
subjects Biomedical and Life Sciences
Dictyota
Dictyota menstrualis
drugs
Ecology
Freshwater & Marine Ecology
gametophytes
Human immunodeficiency virus
Human immunodeficiency virus 1
Life Sciences
Plant Physiology
Plant Sciences
sporophytes
title Variability of a diterpene with potential anti-HIV activity isolated from the Brazilian brown alga Dictyota menstrualis
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