The role of mitochondria in neurodegenerative diseases

Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases, and amyotrophic later...

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Bibliographic Details
Published in:Journal of neurology 2011-10, Vol.258 (10), p.1763-1774
Main Authors: Filosto, Massimiliano, Scarpelli, Mauro, Cotelli, Maria Sofia, Vielmi, Valentina, Todeschini, Alice, Gregorelli, Valeria, Tonin, Paola, Tomelleri, Giuliano, Padovani, Alessandro
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyotrophic lateral sclerosis
Animals
Apoptosis
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Free radicals
Humans
Huntington's disease
Medical sciences
Medicine
Medicine & Public Health
Metabolic pathways
Mitochondria
Mitochondria - metabolism
Mitochondria - pathology
Mitochondrial DNA
Movement disorders
Mutation
Neurodegenerative diseases
Neurodegenerative Diseases - metabolism
Neurodegenerative Diseases - physiopathology
Neurology
Neuroradiology
Neurosciences
Parkinson's disease
Review
Reviews
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Summary:Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-011-6104-z