The role of interleukin DNA polymorphisms in gastric cancer

Abstract Gastric carcinoma is one of the most widespread malignancies worldwide. Interleukins are the key group of cytokines which may have tumor-promoting or tumor-suppressing effect, and receptors for them, of course, have the same importance in this context. However, mechanisms of their impact on...

Full description

Saved in:
Bibliographic Details
Published in:Human immunology 2011-11, Vol.72 (11), p.1128-1136
Main Author: Yuzhalin, Arseniy
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Carcinogenesis
Disease Progression
DNA
Gastric cancer
Genetic Predisposition to Disease
Genotype
Humans
Immunity - genetics
Interleukins
Interleukins - genetics
Polymorphism, Genetic
Single nucleotide polymorphism
Stomach Neoplasms - epidemiology
Stomach Neoplasms - genetics
Stomach Neoplasms - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Gastric carcinoma is one of the most widespread malignancies worldwide. Interleukins are the key group of cytokines which may have tumor-promoting or tumor-suppressing effect, and receptors for them, of course, have the same importance in this context. However, mechanisms of their impact on tumor are not fully understood up to date. Numerous studies provide conflicting data, that makes picture more confusing and complicated. It is known that single nucleotide polymorphisms in interleukin genes may dramatically affect on protein expression level, or alter its functions, which may lead to gastritis or ulcer, and eventually promote cancer occurrence. Furthermore, some of these genetic polymorphisms may serve as predictive factors for cancer prognosis and prevention. In order to understand the impact of each genetic polymorphism, the review of IL-1B, IL-4, IL-6, IL-8, IL-10, IL17A, IL-17F DNA polymorphisms on gastric carcinoma was done, and risk alleles were recommended for further research.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2011.08.003