Efficacy and safety of raltegravir in treatment-experienced HIV-1-infected patients switching from enfuvirtide-based regimens: 48 week results of the randomized EASIER ANRS 138 trial

Objectives To assess the sustainable efficacy and safety of a switch from enfuvirtide to raltegravir in patients with multidrug-resistant HIV infection. Methods One hundred and seventy patients with multidrug-resistant HIV infection and suppressed plasma HIV RNA levels

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 2011-09, Vol.66 (9), p.2099-2106
Main Authors: Gallien, Sébastien, Braun, Joséphine, Delaugerre, Constance, Charreau, Isabelle, Reynes, Jacques, Jeanblanc, François, Verdon, Renaud, de Truchis, Pierre, May, Thierry, Madelaine-Chambrin, Isabelle, Aboulker, Jean-Pierre, Molina, Jean-Michel
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
CD4 Lymphocyte Count
Drug resistance
Drug Resistance, Multiple, Viral
Endpoint Determination
Female
France
Genotype
HIV
HIV Envelope Protein gp41 - therapeutic use
HIV Fusion Inhibitors
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - virology
HIV Integrase Inhibitors - adverse effects
HIV Integrase Inhibitors - therapeutic use
HIV-1
Human immunodeficiency virus
Human immunodeficiency virus 1
Human viral diseases
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Infectious diseases
Male
Medical sciences
Medical treatment
Microbial Sensitivity Tests
Middle Aged
Peptide Fragments - therapeutic use
Pharmacology. Drug treatments
Pilot Projects
Plasma
Prospective Studies
Pyrrolidinones - adverse effects
Pyrrolidinones - therapeutic use
Raltegravir Potassium
Ribonucleic acid
RNA
RNA, Viral - blood
Treatment Outcome
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Description
Summary:Objectives To assess the sustainable efficacy and safety of a switch from enfuvirtide to raltegravir in patients with multidrug-resistant HIV infection. Methods One hundred and seventy patients with multidrug-resistant HIV infection and suppressed plasma HIV RNA levels
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/dkr269