Regioselective deglycosylation of onion quercetin glucosides by Saccharomyces cerevisiae

Bioconversion of quercetin glucosides using four generally recognized as safe (GRAS) organisms (Aspergillus oryzae, Bacillus subtilis, Lactobacillus plantarum, and Saccharomyces cerevisiae) was evaluated by measuring changes in the levels of quercetin compounds of onion. Of the four organisms, S. ce...

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Bibliographic Details
Published in:Biotechnology letters 2011-04, Vol.33 (4), p.783-786
Main Authors: Chung, Dong-Min, Chung, Yung-Chul, Maeng, Pil Je, Chun, Hyo-Kon
Format: Article
Language:English
Subjects:
Allium cepa
Applied Microbiology
Aspergillus oryzae
Bacillus subtilis
Bacteria
Biochemistry
Bioconversions. Hemisynthesis
Biological and medical sciences
Biomedical and Life Sciences
Biotechnology
biotransformation
Fundamental and applied biological sciences. Psychology
Glucosides
Glucosides - analysis
Glucosides - chemistry
Glucosides - metabolism
Glycosylation
isoquercitrin
Lactobacillus plantarum
Life Sciences
Methods. Procedures. Technologies
Microbiology
Molecular Structure
Onions
Onions - chemistry
Organisms
Original Research Paper
quercetin
Quercetin - analogs & derivatives
Quercetin - analysis
Quercetin - chemistry
Quercetin - metabolism
Recognition
Saccharomyces cerevisiae
Saccharomyces cerevisiae - metabolism
Stereoisomerism
Up-Regulation
Yeast
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Summary:Bioconversion of quercetin glucosides using four generally recognized as safe (GRAS) organisms (Aspergillus oryzae, Bacillus subtilis, Lactobacillus plantarum, and Saccharomyces cerevisiae) was evaluated by measuring changes in the levels of quercetin compounds of onion. Of the four organisms, S. cerevisiae increased the content of quercetin-3-O-β-d-glucoside (III; isoquercitrin) and quercetin (IV), whereas decreasing quercetin-3,4′-O-β-d-glucoside (I) and quercetin-4′-O-β-d-glucoside (II). Also, S. cerevisiae converted authentic compound I to III, and II to IV, respectively. These results suggest that S. cerevisiae can be used to increase the levels of isoquercitrin (III), the most bioavailable quercetin compound in onion.
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-010-0501-8