Combination of Melatonin and Alpha Lipoic Acid has Greater Cardioprotective Effect than Either of them Singly Against Cadmium-Induced Oxidative Damage

Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (...

Full description

Saved in:
Bibliographic Details
Published in:Cardiovascular toxicology 2011-03, Vol.11 (1), p.78-88
Main Authors: Mukherjee, Raktim, Banerjee, Sudeep, Joshi, Niraj, Singh, Prem Kumar, Baxi, Darshee, Ramachandran, A. V
Format: Article
Language:English
Subjects:
Acids
Alpha lipoic acid
Animals
Antioxidants
Antioxidants - pharmacology
Ascorbic Acid - metabolism
Biomarkers - metabolism
Biomedical and Life Sciences
Biomedicine
Cadmium
Cadmium Chloride
Cardiology
Cardiotoxicity
Cereals
Chloride
Drug Synergism
Drug Therapy, Combination
Enzymes
Enzymes - metabolism
Female
Free radicals
Glutathione - metabolism
Heart Diseases - chemically induced
Heart Diseases - metabolism
Heart Diseases - pathology
Heart Diseases - prevention & control
Hydrogen Peroxide - metabolism
Hydroxyl Radical - metabolism
Ischemia
Lipid peroxidation
Lipid Peroxidation - drug effects
Malondialdehyde - metabolism
Melatonin
Melatonin - pharmacology
Metallothionein
Metallothionein - metabolism
Myocardium - metabolism
Myocardium - pathology
Oxidative stress
Oxidative Stress - drug effects
Pharmacology/Toxicology
Rats
Thioctic Acid - pharmacology
Vegetables
Vitamin E - metabolism
Zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Present study evaluates cardioprotective role of melatonin (Mel), alpha lipoic acid (ALA), a combination of melatonin and alpha lipoic acid (Mel + ALA) against cadmium (Cd)-induced oxidative damage. Female albino rats were subjected to 15-day exposure to Cd (5.12 mg/kg bw) alone or treated with ML (10 mg/kg bw) + ALA (25 mg/kg bw) simultaneously. Plasma markers of cardiac damage, cardiac free radical generation, lipid peroxidation, endogenous antioxidant status, cadmium load, metallothionein induction, and histopathology were evaluated in various experimental groups. Combination of Mel + ALA significantly prevented leakage of marker enzymes of cardiac damage, changes in cardiac free radical generation, endogenous antioxidants, antioxidant status, structural alterations and augmented the degree of metallothionein (MT) induction. The results demonstrate that ML + ALA co-administration effectively protected against Cd-induced cardiac oxidative damage.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-010-9092-9