Shiga toxin-producing Escherichia coli O157 associated with human infections in Switzerland, 2000–2009

Shiga toxin-producing Escherichia coli (STEC), an important foodborne pathogen, can cause mild to severe bloody diarrhoea (BD), sometimes followed by life-threatening complications such as haemolytic uraemic syndrome (HUS). A total of 44 O157 strains isolated from different patients from 2000 throug...

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Bibliographic Details
Published in:Epidemiology and infection 2011-07, Vol.139 (7), p.1097-1104
Main Authors: KÄPPELI, U., HÄCHLER, H., GIEZENDANNER, N., CHEASTY, T., STEPHAN, R.
Format: Article
Language:English
Subjects:
Adolescent
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antimicrobial agents
Bacteria
Bacteriology
Biological and medical sciences
Child
Child, Preschool
Diarrhea
Diarrhea - epidemiology
Diarrhea - etiology
Diarrhea - microbiology
Disease Outbreaks
Drug Resistance, Bacterial - genetics
E coli
E. coli O157
Electrophoresis, Gel, Pulsed-Field
Epidemiology
Escherichia coli
Escherichia coli Infections - complications
Escherichia coli Infections - epidemiology
Escherichia coli Infections - microbiology
Escherichia coli O157
Escherichia coli O157 - classification
Escherichia coli O157 - drug effects
Escherichia coli O157 - genetics
Family medical history
Feces - microbiology
Female
Fundamental and applied biological sciences. Psychology
Genetic diversity
Hemolytic uremic syndrome
Humans
Infant
Infections
Infectious diseases
Male
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Multilocus Sequence Typing
Polymerase chain reaction
Serotyping
Shiga toxins
Switzerland - epidemiology
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Summary:Shiga toxin-producing Escherichia coli (STEC), an important foodborne pathogen, can cause mild to severe bloody diarrhoea (BD), sometimes followed by life-threatening complications such as haemolytic uraemic syndrome (HUS). A total of 44 O157 strains isolated from different patients from 2000 through 2009 in Switzerland were further characterized and linked to medical history data. Non-bloody diarrhoea was experienced by 15·9%, BD by 61·4% of the patients, and 29·5% developed HUS. All strains belonged to MLST type 11, were positive for stx2 variants (stx2 and/or stx2c), eae and ehxA, and only two strains showed antibiotic resistance. Of the 44 strains, nine phage types (PTs) were detected the most frequent being PT32 (43·2%) and PT8 (18·2%). By PFGE, 39 different patterns were found. This high genetic diversity within the strains leads to the conclusion that STEC O157 infections in Switzerland most often occur as sporadic cases.
ISSN:0950-2688
1469-4409
DOI:10.1017/S0950268810002190