Evaluation of species distribution and risk factors of candidemia: A multicenter case-control study

This study was planned to determine the risk factors of candidemia, and the most common Candida species causing bloodstream infections. A case-control study which included adult patients was conducted over a 1-year period at tertiary-care educational hospitals in Turkey. A total of 83 candidemia epi...

Full description

Saved in:
Bibliographic Details
Published in:Medical mycology (Oxford) 2011-01, Vol.49 (1), p.26-31
Main Authors: Yapar, Nur, Pullukcu, Husnu, Avkan-Oguz, Vildan, Sayin-Kutlu, Selda, Ertugrul, Bulent, Sacar, Suzan, Cetin, Banu, Kaya, Onur
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Candida - classification
Candida - isolation & purification
Candida albicans
Candida glabrata
Candida parapsilosis
Candida tropicalis
Candidemia - epidemiology
Candidemia - microbiology
Case-Control Studies
Female
Hospitals, University
Humans
Male
Middle Aged
Risk Factors
Turkey - epidemiology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study was planned to determine the risk factors of candidemia, and the most common Candida species causing bloodstream infections. A case-control study which included adult patients was conducted over a 1-year period at tertiary-care educational hospitals in Turkey. A total of 83 candidemia episodes were identified during the study period. Candida albicans was the most common species recovered (45.8%) followed by Candida tropicalis (24.1%) Candida parapsilosis (14.5%) and Candida glabrata which was isolated from only four (4.8%) patients. Presence of a urethral catheter (odds ratio [OR] 2.38; 95% confidence interval [CI] 1.09-5.19; P = 0.02), previous use of antibiotics (OR 2.61; 95% CI 1.05-6.46; P = 0.03), RBC transfusions (OR 2.14; 95% CI 1.16-3.94; P = 0.01) and parenteral nutrition (OR 4.44; 95% CI 2.43-8.11; P < 0.01) were found as independent risk factors for candidemia. TPN (Total Parenteral Nutrition) was an independent risk factor for both C. albicans and non-Candida albicans Candida species (P < 0.001). Most of the risk factors were invasive procedures and former medications. We conclude that a great number of candidemia cases are preventable by means of reduction of unnecessary invasive procedures and the use of antimicrobials.
ISSN:1369-3786
1460-2709
DOI:10.3109/13693786.2010.501344