Clinical effects of insular damage in humans

Multiple disturbances following lesions of the insula are reviewed in the present article, including those related to autonomic function; gustatory, olfactory, auditory, somatosensory, and multimodal perception, as well as body awareness; the emotion of disgust; mood and willed action, addiction beh...

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Bibliographic Details
Published in:Brain Structure and Function 2010-06, Vol.214 (5-6), p.397-410
Main Authors: Ibañez, Agustin, Gleichgerrcht, Ezequiel, Manes, Facundo
Format: Article
Language:English
Subjects:
Animals
Awareness - physiology
Biomedical and Life Sciences
Biomedicine
Brain Damage, Chronic - pathology
Brain Damage, Chronic - physiopathology
Brain research
Cell Biology
Cerebral Cortex - anatomy & histology
Cerebral Cortex - physiology
Emotions
Humans
Nerve Net - anatomy & histology
Nerve Net - physiology
Neurology
Neurosciences
Pain - physiopathology
Pain - psychology
Perception - physiology
Review
Sensory perception
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Summary:Multiple disturbances following lesions of the insula are reviewed in the present article, including those related to autonomic function; gustatory, olfactory, auditory, somatosensory, and multimodal perception, as well as body awareness; the emotion of disgust; mood and willed action, addiction behavior, and language. Given the multiple and varied nature of the impairments revealed by lesion studies, we suggest that the insula, as a multimodal area, has a major role as a convergence zone implicated in the coordination between internal and external information through emotional subjective awareness. Methodological issues are discussed with attention paid to lesion etiology, and lesions involving adjacent areas to the insular cortex.
ISSN:1863-2653
1863-2661
0340-2061
DOI:10.1007/s00429-010-0256-y