Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: Possible implications for the pharmacotherapy of autism spectrum disorders

Highlights ► NMDA receptor hypofunction is associated with impaired sociability. ► MPEP diminished spontaneous stereotypic behaviors in mice. ► MPEP has complex and inconsistent effects on sociability. ► Stimulation of mGluR5 activates NMDA receptors. ► Positive allosteric modulation of mGluR5 may t...

Full description

Saved in:
Bibliographic Details
Published in:Brain research bulletin 2011-10, Vol.86 (3), p.152-158
Main Authors: Burket, Jessica A, Herndon, Amy L, Winebarger, Erin E, Jacome, Luis F, Deutsch, Stephen I
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Autism spectrum disorders
Balb/c mice
Child
Child Development Disorders, Pervasive - drug therapy
Child Development Disorders, Pervasive - psychology
Excitatory Amino Acid Antagonists - pharmacology
Grooming - drug effects
Humans
Interpersonal Relations
Male
Metabotropic glutamate receptors
Mice
Mice, Inbred BALB C
MPEP
Neurology
NMDA receptor
Pyridines - pharmacology
Receptor, Metabotropic Glutamate 5
Receptors, Metabotropic Glutamate - antagonists & inhibitors
Receptors, N-Methyl-D-Aspartate - drug effects
Sociability
Social Behavior
Stereotyped Behavior - drug effects
Stereotypies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► NMDA receptor hypofunction is associated with impaired sociability. ► MPEP diminished spontaneous stereotypic behaviors in mice. ► MPEP has complex and inconsistent effects on sociability. ► Stimulation of mGluR5 activates NMDA receptors. ► Positive allosteric modulation of mGluR5 may target impaired sociability.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.08.001