Duration of the cell cycle phases in mutants for the tumor suppressor Merlin in Drosophila melanogaster

The cell cycle duration was estimated in Drosophila melanogaster mutants for the tumor suppressor Merlin with the use of different approaches. Experiments on induction of mosaic clones in tissues of the larval wing imaginal disc showed that the cell cycle in mutant discs is shorter than that in cont...

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Bibliographic Details
Published in:Russian journal of genetics 2011-04, Vol.47 (4), p.404-408
Main Authors: Dubatolova, T. D., Dorogova, N. V., Omel’yanchuk, L. V., Chang, L. -Sh
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Drosophila melanogaster
General Genetics
Human Genetics
Microbial Genetics and Genomics
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Summary:The cell cycle duration was estimated in Drosophila melanogaster mutants for the tumor suppressor Merlin with the use of different approaches. Experiments on induction of mosaic clones in tissues of the larval wing imaginal disc showed that the cell cycle in mutant discs is shorter than that in control. Flow fluorescence cytometry revealed no differences between mutant and normal animals in the relative duration of the cell cycle phases, which suggests proportional shortening of the cell cycle phases. The study with pulselabeled mitoses confirmed these results and showed that the length of the cell cycle is 7 h (S phase duration 3 h) in control individuals and 5 h (S phase duration 2 h) in Merlin gene mutants.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795411040041