Usefulness of thallium-201 SPECT in the evaluation of tumor natures in intracranial meningiomas

Introduction Although intracranial meningiomas are regarded as benign tumors, some of them behave clinically as malignant tumors. Past reports suggest that MIB 1 and vascular endothelial growth factor (VEGF) in postoperative tumor specimens correlate with the aggressive nature of tumors, but preoper...

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Bibliographic Details
Published in:Neuroradiology 2011-11, Vol.53 (11), p.867-873
Main Authors: Takeda, Tetsuji, Nakano, Takahiro, Asano, Kenichiroh, Shimamura, Norihito, Ohkuma, Hiroki
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Brain
Diagnostic Neuroradiology
Electrodiagnosis. Electric activity recording
Female
Humans
Imaging
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical imaging
Medical sciences
Medicine
Medicine & Public Health
Meningeal Neoplasms - diagnostic imaging
Meningeal Neoplasms - pathology
Meningioma - diagnostic imaging
Meningioma - pathology
Middle Aged
Nervous system
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiology
Thallium Radioisotopes
Tomography, Emission-Computed, Single-Photon - methods
Tumors
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Summary:Introduction Although intracranial meningiomas are regarded as benign tumors, some of them behave clinically as malignant tumors. Past reports suggest that MIB 1 and vascular endothelial growth factor (VEGF) in postoperative tumor specimens correlate with the aggressive nature of tumors, but preoperative prediction of such a nature is more useful for therapeutic planning for the tumor. The purpose of this study was to assess the usefulness of preoperative thallium-201 chloride single-photon emission computed tomography (Tl SPECT) to evaluate biological behavior in intracranial meningiomas. Methods Tl SPECT was performed on 39 patients with intracranial meningioma and Tl uptake indices were calculated. The difference in the Tl uptake index between atypical meningiomas and other pathological types of meningioma was evaluated. Moreover, correlation of Tl uptake indices with the MIB1 labeling index was estimated. Tl uptake indices were also compared between VEGF strongly positive and weakly positive meningiomas. Results The delayed index of atypical meningioma was significantly higher than that of the other pathological types ( p  = 0.036). Significant correlation was found between the Tl uptake index in the delayed image and MIB1 labeling index ( p  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-010-0822-2