Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain

Resveratrol is a plant polyphenolic compound. Evidence indicates that resveratrol has beneficial effects against aging and neurodegenerative diseases. The goal of our study was in vivo examination of the effects of resveratrol on the abundance of mRNA encoding Brain Derived Neurotrophic Factor (BDNF...

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Published in:Neurochemical research 2011-05, Vol.36 (5), p.761-765
Main Authors: Rahvar, Mostafa, Nikseresht, Mohsen, Shafiee, Sayed Mohammad, Naghibalhossaini, Fakhraddin, Rasti, Mozhgan, Panjehshahin, Mohammad Reza, Owji, Ali Akbar
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Base Sequence
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain-Derived Neurotrophic Factor - genetics
Cell Biology
DNA Primers
Gene Expression - drug effects
Hippocampus - drug effects
Hippocampus - metabolism
Male
Neurochemistry
Neurology
Neurosciences
Original Paper
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Stilbenes - administration & dosage
Stilbenes - pharmacology
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container_issue 5
container_start_page 761
container_title Neurochemical research
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creator Rahvar, Mostafa
Nikseresht, Mohsen
Shafiee, Sayed Mohammad
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Rasti, Mozhgan
Panjehshahin, Mohammad Reza
Owji, Ali Akbar
description Resveratrol is a plant polyphenolic compound. Evidence indicates that resveratrol has beneficial effects against aging and neurodegenerative diseases. The goal of our study was in vivo examination of the effects of resveratrol on the abundance of mRNA encoding Brain Derived Neurotrophic Factor (BDNF) in the hippocampus of rat brain. Rats were administrated orally by different doses (2.5–20 mg/kg bwt) of resveratrol for 3, 10 and 30 days. Saline was used as control and 10% ethanol in saline was used as vehicle for resveratrol. Measurement of BDNF mRNA by Real-time RT–PCR showed that levels of the mRNA for BDNF were significantly and dose dependently elevated in the hippocampal tissues of rats. The findings suggest that the neuroprotective effects of resveratrol may be at least partly due to its inducing effects on the expression levels of the BDNF mRNA.
doi_str_mv 10.1007/s11064-010-0396-8
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subjects Administration, Oral
Animals
Antioxidants - administration & dosage
Antioxidants - pharmacology
Base Sequence
Biochemistry
Biomedical and Life Sciences
Biomedicine
Brain-Derived Neurotrophic Factor - genetics
Cell Biology
DNA Primers
Gene Expression - drug effects
Hippocampus - drug effects
Hippocampus - metabolism
Male
Neurochemistry
Neurology
Neurosciences
Original Paper
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
Stilbenes - administration & dosage
Stilbenes - pharmacology
title Effect of Oral Resveratrol on the BDNF Gene Expression in the Hippocampus of the Rat Brain
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