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Therapeutic applications of ribozymes and riboswitches
Therapeutic approaches employing RNA as a tool or as a drug target have recently emerged and have been employed for various applications—ranging from cancer treatment to virus infection. Despite the paucity of its molecular groups compared to proteins, RNA has nevertheless proved to be an excellent...
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Published in: | Current opinion in pharmacology 2010-10, Vol.10 (5), p.551-556 |
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creator | Mulhbacher, Jérôme St-Pierre, Patrick Lafontaine, Daniel A |
description | Therapeutic approaches employing RNA as a tool or as a drug target have recently emerged and have been employed for various applications—ranging from cancer treatment to virus infection. Despite the paucity of its molecular groups compared to proteins, RNA has nevertheless proved to be an excellent choice for researchers who have aspired to develop therapeutic tools. Ribozymes and riboswitches are RNA-based therapeutic tools that are most often employed to knockdown gene expression and to inhibit bacterial infections, respectively. The aim of this review is to summarize recent advances observed in ribozyme- and riboswitch-based therapeutic applications that, in some cases, have reached clinical trials. |
doi_str_mv | 10.1016/j.coph.2010.07.002 |
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subjects | Gene Knockdown Techniques Genetic Therapy HIV Infections - genetics HIV Infections - therapy Humans Internal Medicine Medical Education Neoplasms - genetics Neoplasms - therapy Prion Diseases - genetics Prion Diseases - therapy Riboswitch - physiology RNA, Catalytic - genetics RNA, Catalytic - therapeutic use |
title | Therapeutic applications of ribozymes and riboswitches |
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