Anti-inflammatory effect of Acacia visco extracts in animal models

• Published in: Inflammopharmacology 2010-10, Vol.18 (5), p.253-260
• Main Authors: Pedernera, Ana María, Guardia, Teresita, Guardia Calderón, Carola Elisa, Rotelli, Alejandra Ester, de la Rocha, Nadir Ernesto, Saad, José Roberto, Lopez Verrilli, María Alejandra, Garcia Aseff, Susana, Pelzer, Lilian Eugenia
• Format: Article
• Language: English
• Subjects: Acacia; Allergology; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - toxicity; Biomedical and Life Sciences; Biomedicine; Carrageenan; Dermatology; Edema - chemically induced; Edema - pathology; Edema - prevention & control; Fabaceae; Female; Gastroenterology; Granuloma - chemically induced; Granuloma - prevention & control; Immunology; Male; Mice; Oleanolic Acid - analogs & derivatives; Oleanolic Acid - therapeutic use; Pentacyclic Triterpenes - therapeutic use; Pharmacology/Toxicology; Phospholipases A2; Phytotherapy; Plant Extracts - pharmacology; Plant Extracts - toxicity; Plant Leaves; Rats; Rats, Wistar; Research Article; Rheumatology
• ISSN: 0925-4692; 1568-5608
• DOI: 10.1007/s10787-009-0028-6

The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for anti-inflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed anti-inflammatory effect against carrageenan-induced oedema, phospholipase A 2 -induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3β-ol (lupeol), 12-ursen-3β-ol (α-amyrin) and 12-oleanen-3β-ol (β-amyrin) may be mainly responsible for the pharmacological activities.