Expression of the PI4P 5-kinase Drosophila homologue skittles in the germline suggests a role in spermatogenesis and oogenesis

We have isolated the Drosophila gene skittles (sktl) which shows homology to members of a novel family of phosphatidylinositol-4-phosphate 5-kinases, including the gene product encoded by the human STM-7.I gene which has been assigned to the neurodegenerative disorder Friedreichs ataxia. In situ hyb...

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Bibliographic Details
Published in:Development genes and evolution 1997-07, Vol.207 (2), p.127-130
Main Authors: Knirr, Stefan, Santel, Ansgar, Renkawitz-Pohl, R
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol-4-phosphate 5-kinase
Drosophila
Evolutionary genetics
Friedreich's ataxia
Homology
Insects
Kinases
Neurodegenerative diseases
Oogenesis
Spermatogenesis
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Summary:We have isolated the Drosophila gene skittles (sktl) which shows homology to members of a novel family of phosphatidylinositol-4-phosphate 5-kinases, including the gene product encoded by the human STM-7.I gene which has been assigned to the neurodegenerative disorder Friedreichs ataxia. In situ hybridization reveals sktl expression during oogenesis and spermatogenesis.
ISSN:0949-944X
1432-041X
DOI:10.1007/s004270050099