Ferulic acid-induced anti-depression and prokinetics similar to Chaihu–Shugan–San via polypharmacology

Highlights ► We used ferulic acid (FA) to treat depression and prokinetics disorders by polypharmacology. ► The treatment avoided the shortcoming of discontinue for “one-compound-one-target” paradigm. ► FA was detected in hippocampus and small intestine by UPLC after oral Chaihu–Shugan–San. ► The mo...

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Bibliographic Details
Published in:Brain research bulletin 2011-10, Vol.86 (3), p.222-228
Main Authors: Zhang, Ying-jin, Huang, Xi, Wang, Yang, Xie, Ying, Qiu, Xin-jiang, Ren, Ping, Gao, Li-chen, Zhou, Hong-hao, Zhang, Hui-yun, Qiao, Ming-qi
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - metabolism
Animals
Anti-depression
Antidepressive Agents
Antidepressive Agents, Second-Generation - pharmacology
Biogenic Monoamines - metabolism
Chromatography, High Pressure Liquid
Corticotropin-Releasing Hormone - metabolism
Coumaric Acids - analysis
Coumaric Acids - pharmacology
Ferulic acid
Fluoxetine - pharmacology
Gastrointestinal Motility - drug effects
Ghrelin - metabolism
Isometric Contraction - drug effects
Jejunum - drug effects
Male
Mass Spectrometry
Motor Activity - drug effects
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Muscle, Smooth - metabolism
Neurology
Plant Extracts - pharmacology
Polypharmacology
Polypharmacy
Prokinetics
Rats
Rats, Sprague-Dawley
Serotonin - metabolism
Swimming - psychology
Traditional Chinese medicine
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Summary:Highlights ► We used ferulic acid (FA) to treat depression and prokinetics disorders by polypharmacology. ► The treatment avoided the shortcoming of discontinue for “one-compound-one-target” paradigm. ► FA was detected in hippocampus and small intestine by UPLC after oral Chaihu–Shugan–San. ► The monoamine mechanism of FA's anti-depression was studied. ► We claimed to treat depression by multi-target theory.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.07.002