Maintenance of the patterns of expression of homeotic genes in the development of Drosophila melanogaster by proteins of the polycomb, trithorax, and ETP groups

Proteins encoded by genes of the Polycomb (PcG), trithorax (trxG), and the Enhancer of trithorax and Polycomb (ETP) groups are important regulators of expression of most developmental genes. Data concerning all currently described genes assigned to these groups are summarized in the review. Genetic...

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Bibliographic Details
Published in:Russian journal of genetics 2009-10, Vol.45 (10), p.1145-1161
Main Authors: Fedorova, E. V, Pindyurin, A. V, Baricheva, E. M
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Drosophila melanogaster
Human Genetics
Microbial Genetics and Genomics
Reviews and Theoretical Articles
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Summary:Proteins encoded by genes of the Polycomb (PcG), trithorax (trxG), and the Enhancer of trithorax and Polycomb (ETP) groups are important regulators of expression of most developmental genes. Data concerning all currently described genes assigned to these groups are summarized in the review. Genetic interactions of these genes and phenotypic manifestation of their mutations are described. Data on the PcG, trxG, and ETP proteins are systematized. Questions are considered concerning the formation of multimeric complexes containing proteins of these groups, recruitment of these complexes to regulatory elements of target genes, and the mechanisms of activation/repression of gene expression.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795409100019