MEMS biosensors for detection of methicillin resistant Staphylococcus aureus

This review presents the current state of the conventional methods, microfluidic based biosensors, and the commercial products used in the detection of methicillin resistant Staphylococcus aureus (MRSA), which is one of the most important threats of nosocomial infections in many parts of the world....

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Bibliographic Details
Published in:Biosensors & bioelectronics 2011-11, Vol.29 (1), p.1-12
Main Authors: Ceylan Koydemir, Hatice, Külah, Haluk, Özgen, Canan, Alp, Alpaslan, Hasçelik, Gülşen
Format: Article
Language:English
Subjects:
Bacteriological Techniques
Biosensing Techniques - instrumentation
Biosensing Techniques - methods
Biosensing Techniques - statistics & numerical data
Biosensors
Cross Infection - diagnosis
Cross Infection - prevention & control
Detection
Equipment Design
Humans
MEMS
Methicillin Resistance
Methicillin-Resistant Staphylococcus aureus - drug effects
Methicillin-Resistant Staphylococcus aureus - isolation & purification
Micro-Electrical-Mechanical Systems - instrumentation
Micro-Electrical-Mechanical Systems - methods
Micro-Electrical-Mechanical Systems - statistics & numerical data
Microfluidic Analytical Techniques
MRSA
Staphylococcal Infections - diagnosis
Staphylococcal Infections - prevention & control
Staphylococcus aureus
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Summary:This review presents the current state of the conventional methods, microfluidic based biosensors, and the commercial products used in the detection of methicillin resistant Staphylococcus aureus (MRSA), which is one of the most important threats of nosocomial infections in many parts of the world. The early detection of MRSA in the specimens of the patients is important to enable the appropriate treatment, to decrease morbidity and mortality rates, and to manage control actions in the healthcare units. Thus, rapid and inexpensive diagnostic systems with high sensitivity and specificity are essential to prevent MRSA to be an emerging public health threat. The design and fabrication of new diagnostic systems necessitates working in collaboration between different disciplines to make new challenges in the field of clinical diagnosis and to meet the demands of clinicians. It is certain that in the near future, MEMS and nanotechnology based detection methods will take the place of current methods in clinical diagnosis. The evaluation of new trends for specificity, sensitivity, cost effectiveness, disposability, low weight, ease of use, and facile access should be taken into consideration.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2011.07.071