Design of interior-functionalized fully acetylated dendrimers for anticancer drug delivery

Abstract In this study, dendrimers was synthesized by introducing functional groups into the interior pockets of fully acetylated dendrimers. NMR techniques including COSY and 2D-NOESY revealed the molecular structures of the synthesized dendrimers and the encapsulation of guest molecule such as met...

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Bibliographic Details
Published in:Biomaterials 2011-12, Vol.32 (36), p.9950-9959
Main Authors: Hu, Jingjing, Su, Yunzhang, Zhang, Hongfeng, Xu, Tongwen, Cheng, Yiyun
Format: Article
Language:English
Subjects:
Acetylation
Acetylation - drug effects
Advanced Basic Science
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Death - drug effects
Cell Line, Tumor
Dendrimer
Dendrimers - chemical synthesis
Dendrimers - chemistry
Dentistry
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug Delivery Systems - methods
Humans
Hydrogen-Ion Concentration - drug effects
Interior-functionalized
Magnetic Resonance Spectroscopy
Methotrexate - chemistry
Methotrexate - pharmacology
NMR
Non-toxic
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Summary:Abstract In this study, dendrimers was synthesized by introducing functional groups into the interior pockets of fully acetylated dendrimers. NMR techniques including COSY and 2D-NOESY revealed the molecular structures of the synthesized dendrimers and the encapsulation of guest molecule such as methotrexate within their interior pockets. The synthesized polymeric nanocarriers showed much lower cytotoxicity on two cell lines than cationic dendrimers, and exhibited better performance than fully acetylated dendrimers in the sustained release of methotrexate. The results provided a new strategy in the design of non-toxic dendrimers with high performance in the delivery of anti-cancer drugs for clinical applications.
ISSN:0142-9612
1878-5905
DOI:10.1016/j.biomaterials.2011.09.016